Membranous Nephropathy
Conditions
Interventions
Treatment Group:Danggui Shaoyao San Granules Combined with Western Medicine Basic Therapy
Placebo Group:Placebo TCM Granules Combined with Western Medicine Basic Therapy
Sponsors
Taihe Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Aged 18-70 years; Diagnosed with idiopathic membranous nephropathy (MN) at low or moderate risk based on Western medical criteria; Meeting traditional Chinese medicine (TCM) pattern differentiation criteria for blood stasis and dampness syndrome; Compliance with clinical ethics standards, voluntary participation, and signed informed consent.
Exclusion criteria
Exclusion criteria: Pregnancy and lactation; Allergic constitution or hypersensitivity to the investigational drug; Combined cardiac, cerebral, or hepatic dysfunction; Comorbid malignancies or infectious diseases; Psychiatric disorders, poor compliance, or inability to adhere to treatment; Intolerance to ACEI/ARB therapy (e.g., bilateral renal artery stenosis, hyperkalemia, solitary kidney); High or very high-risk membranous nephropathy (MN) patients; Secondary MN cases (e.g., diabetic nephropathy, Henoch-Schönlein purpura nephritis, lupus nephritis, renal amyloidosis, hepatitis B, malignancy, drug-induced, or infection-related MN).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour Proteinuria;Serum Albumin;Serum Creatinine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Urine Albumin-to-Creatinine Ratio;Serum Anti-Phospholipase A2 Receptor Antibody;TCM Syndrome Score;Plasma D-Dimer;Coagulation Function;Blood Lipids;Renal Function; | — |
Countries
China
Contacts
Public ContactKun Zhang
Taihe Hospital of Traditional Chinese Medicine
Outcome results
None listed