Migraine without aura
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: The content meets the diagnostic criteria for migraine without aura according to the third edition of the International Classification of Headache Disorders (ICHD-3), combined with previous research literature (JAMA Internal Medicine, 2017). 1) Age between 18 and 55 years, regardless of gender; 2) At least 1 year of migraine history, with the age at first onset less than 50 years; 3) Right-handed, with education duration =6 years; 4) At least 2 migraine episodes in the past 4 weeks, with monthly attack days <15 days; 5) VAS score between 3 and 7; 6) Able to complete a headache diary independently; 7) Signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of head trauma, secondary headaches, tension-type headaches, intermittent headaches, cluster headaches, and cardiovascular and digestive system diseases; 2) Those who have undergone major intestinal resection or large gastrointestinal surgery in the past; 3) Individuals with mental illness, infections, bleeding disorders, or allergic constitutions; 4) Pregnant women, breastfeeding women, or those planning to become pregnant within the next 6 months; 5) Those unable to understand or record headache diaries; 6) Presence of contraindications for MRI; 7) Use of antibiotics or acupuncture treatment within the past 3 months, lasting 3 days or more; 8) Long-term use of pain medications and drugs for migraine prevention; 9) Participation in similar studies within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of days with headache attacks;headache attack frequency;Headache Duration;Visual Analog Scale (VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Migraine-Specific Quality of Life Questionnaire (MSQ);Self-Rating Anxiety Scale (SAS);Self-Rating Depression Scale (SDS);Pittsburgh Sleep Quality Index (PSQI); | — |
Countries
China
Contacts
Fujian University of Traditional Chinese Medicine Affiliated Hospital of Rehabilitation, Fujian University of Traditional Chinese Medicine