Postoperative gastrointestinal dysfunction
Conditions
Interventions
Wuda Granule Treatment Group:Wuda Granule (10 g/bag), provided by the Preparation Room of Guangdong Provincial Hospital of Chinese Medicine. Drug composition: Amomi Fructus, Linderae Radix, Ginseng Ra
Placebo Control Group:Placebo Granules (10 g/bag), provided by the Preparation Room of Guangdong Provincial Hospital of Chinese Medicine, mainly consist of liquid caramel, dextrin, and a bittering age
Sponsors
Department of Hepatobiliary Surgery Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 80 years (inclusive) 2.Diagnosed with liver cancer and scheduled for laparoscopic liver resection 3.Operative time = 4 hours 4.Liver resection extent < 50% 5.Child-Pugh Class A liver function 6.Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score 0-1 7.Signed informed consent obtained
Exclusion criteria
Exclusion criteria: 1.Patients with concurrent portal hypertension 2.Patients with concurrent portal vein tumor thrombus (PVTT) 3.Combined resection of other organs besides gallbladder 4.Intraoperative blood loss > 800 ml 5.Receipt of preoperative conversion therapy 6.History of prior abdominal surgery 7.Diagnosis of psychiatric disorders 8.Pregnancy or lactation 9.Allergy to investigational drugs 10.Patients who are currently participating or have participated in other clinical trials within 1 month prior to enrollment in this study. 11.Patients deemed by the investigator as unsuitable for participation in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to First Flatus After Surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Corticotropin releasing hormone;Incidence of Postoperative Bowel Obstruction;Clavien-Dindo Classification of Surgical Complications;Time to First Defecation After Surgery;Time to First Oral Diet Tolerance After Surgery;Perioperative Gastrointestinal Symptom Score;Postoperative Length of Stay;Bowel Sound Recovery Time;Ghrelin;Intake Feeling nauseated Emesis Exam and Duration of symptoms scoring systemIntake Feeling nauseated Emesis Exam and Duration of symptoms scoring system;Superoxide Dismutase;Tumor Necrosis Factor;Identity-Consequence Fatigue Scale;Visual Analogue Scale;Malondialdehyde;Interleukin-6;Qi Deficiency and Qi Stagnation Syndrome Scale; | — |
Countries
China
Contacts
Public ContactJunming He
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed