hypertension
Conditions
Interventions
Placebo group:On the basis of lowering blood pressure and protecting renal function RAS system inhibitor is combined with placebo granules
Huoxue Qianyang Granule Group:RAS system inhibitor combined with Huoxue Qianyang Granule on the basis of lowering blood pressure.
Sponsors
Longhua Hospital of Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients meeting the diagnostic criteria for primary hypertension according to the 2024 Chinese Guidelines for Hypertension Diagnosis and Treatment, and receiving at least one type of RAS inhibitor. (2) Meeting the diagnostic criteria for early-stage hypertensive renal impairment. (3) Meeting the diagnostic criteria for the TCM syndrome pattern of "blood stasis with yang hyperactivity". (4) Age 35–80 years. (5) Voluntarily participating and having signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Failure to meet the inclusion criteria. (2) Patients with glaucoma. (3) Patients with dizziness or headache caused by other conditions (e.g., anemia, hyperthyroidism, severe neurosis, cervical spondylosis, tumors, hypotension). (4) Patients with severe primary diseases (cerebrovascular, hepatic, renal, hematopoietic system disorders) or severe cardiac dysfunction, or psychiatric disorders. (5) Pregnant or lactating women, or women planning pregnancy. (6) Patients with congenital heart disease, valvular heart disease, cor pulmonale, cardiomyopathy, pericardial effusion, or pleural effusion confirmed by physical or auxiliary examinations. (7) Patients with secondary hypertension. (8) Patients with refractory hypertension. (9) Patients with allergic constitutions or multiple drug allergies. (10) Patients meeting inclusion criteria but excluded due to non-adherence to protocol-specified medication, unevaluable efficacy, or incomplete data affecting safety/efficacy assessment.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Integrals of TCM syndromes;kidney function;24-hour mean blood pressure(ABP);Urinary Albumin-to-Creatinine Ratio (UACR);cystatin c;Glomerular Filtration Rate (GFR); | — |
Primary
| Measure | Time frame |
|---|---|
| Urinary Microalbumin(MAU); | — |
Countries
China
Contacts
Public ContactWang.Zheng
Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed