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Clinical efficacy and mechanism of Longsha Yunqi acupuncture in treating coronary microvascular angina (qi stagnation and blood stasis syndrome)

Clinical efficacy and mechanism of Longsha Yunqi acupuncture in treating coronary microvascular angina (qi stagnation and blood stasis syndrome)

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001940
Enrollment
Unknown
Registered
2025-10-15
Start date
2025-09-20
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary microvascular angina

Interventions

intervention group :Electroacupuncture
control group:Sham Electroacupuncture

Sponsors

Wuxi Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Typical symptoms of exertional angina (Canadian Cardiovascular Society class I to III). (2) Coronary angiography showing stenosis of epicardial vessels < 50%. (3) Coronary Angiography-derived Index of Microcirculatory Resistance = 25. (4) Aged 30 to 80 years, regardless of gender. (5) Pattern differentiation based on Traditional Chinese Medicine (Qi Stagnation and Blood Stasis Pattern): Chest pain characterized as stabbing or pricking, fixed in location, which may radiate to the back and vice versa, prolonged and refractory, aggravated by rage. Accompanying signs include a dark red or purple-dark tongue with ecchymosis, sublingual collateral engorgement, thin coating, and a wiry-choppy, intermittent, or rapid pulse. (6) Signed informed consent obtained from the patient.

Exclusion criteria

Exclusion criteria: (1) Severe valvular heart disease, cardiomyopathy, or pericardial disease. (2) Uncontrolled hypertension (blood pressure > 160/100 mmHg) or diabetes (HbA1c > 9%). (3) Hepatic or renal insufficiency (eGFR < 60 ml/min/1.73m²). (4) Presence of psychiatric disorders or inability to cooperate with the treatment.

Design outcomes

Primary

MeasureTime frame
Coronary Angiography-Derived Microvascular Resistance Index (caIMR);Seattle Angina Questionnaire;Cardiopulmonary Exercise Testing;—

Secondary

MeasureTime frame
6-Minute Walk Test;Canadian Cardiovascular Society Grading of Angina Pectoris;Serum Interleukin-6 level;Serum Tumor Necrosis Factor-alpha level;Serum Malondialdehyde level;Serum Superoxide Dismutase level;Serum Nitric Oxide (NO) metabolites (nitrate/nitrite) concentrations;Electrocardiogram;Differentially Expressed miRNAs in Plasma Exosomes;—

Countries

China

Contacts

Public ContactGao Feng

Wuxi Hospital of Traditional Chinese Medicine

qwevip1234@163.com15961898830

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026