Mild cognitive impairment associated with cerebral small vessel disease
Conditions
Interventions
observation group:Du Moxibustion and basic treatment
control group:basic treatment
Sponsors
The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: CSVD-MCI was diagnosed per the Clinical Practice Guideline for Cognitive Impairment of Cerebral Small Vessel Disease of China (2019). 1. Meets the diagnostic criteria for mild cognitive impairment related to cerebral small vessel disease 1.1 Confirm the presence of cerebral small vessel disease (CSVD) with at least one of the following pieces of evidence: (1) Multiple lacunar infarctions in the white matter and deep gray matter;(2) Ischemic white matter changes;(3) Dilated perivascular spaces;(4) Cortical microinfarctions and microbleeds. 1.2 Presence of mild cognitive impairment (MCI) Cognitive decline occurs in one or more cognitive domains, and the cognitive impairment is not severe enough to affect the independence in daily life. 1.3 Confirm relevant evidence that cerebral small vessel disease causes cognitive impairment: (1) Clinical evidence: Either 1) or 2). 1) The cognitive impairment has a temporal and location correlation with cerebral small vessel disease events. Evidence of cerebrovascular events includes: documented history of stroke and stroke-related signs;2) No cerebrovascular events occur, but there is significant impairment in information processing speed, complex attention, and executive function, accompanied by at least one of the following symptoms: early gait disturbance, early urinary control disorder (unexplainable by urinary system diseases), and personality or emotional disorders. (2) Imaging evidence of cerebral small vessel disease is sufficient to explain the existing cognitive impairment: Either 1) or 2). 1) Presence of more than 2 lacunar infarctions outside the brainstem; or 1-2 lacunar infarctions in key locations combined with extensive white matter hyperintensities (WMHs);2) Extensive and severe WMHs: extensive periventricular and deep cerebral white matter lesions, including extensive "caps" (measuring >10 mm parallel to the ventricles), or irregular "halos" (measuring >10 mm in width perpendicular to the ventricles, with periventricular white matter lesions showing irregular edges extending to the deep brain), or diffuse confluent WMHs (>25 mm in size, irregular shape), or extensive white matter changes (diffuse WMHs without focal lesions) combined with lacunar infarctions in the deep gray matter. 2. 19 points = MoCA = 25 points 3. 50 years old = 80 years old 4. Not receiving any cognitive improvement medication within the past 2 months 5. Voluntarily participate in the experiment, communicate without difficulty, cooperate with treatment and examination, and sign an informed consent form
Exclusion criteria
Exclusion criteria: (1) Exclude other imaging changes or diseases that are sufficient to explain memory or other cognitive impairments, such as cortical and/or subcortical non lacunar infarctions, cerebral hemorrhage; (2) Special causes of white matter in the brain (multiple sclerosis, sarcoidosis, brain radiotherapy); (3) Brain lesions (such as Alzheimer's disease, Lewy body dementia, frontotemporal dementia, Parkinson's disease, tumors, hydrocephalus, trauma, syphilis, acquired immunodeficiency syndrome, Creutzfeldt Jakob disease, etc.); (4) Serious mental illness, epilepsy, alcohol and drug abuse, poisoning, and metabolic abnormalities; (5) Suffering from severe organ failure, serious cardiovascular and cerebrovascular diseases, cerebrovascular accidents, malignant tumors, and being equipped with pacemakers, which cannot ensure the smooth completion of the experiment; (6) Severe neurological deficits such as hemiplegia, aphasia, dementia, spasms, and temperature sensitivity disorders exist; (7) Pregnant and lactating women; (8) Individuals who are allergic to moxa and ginger used in therapy, as well as those with local skin damage; (9) Individuals with yin deficiency and excessive fire, external wind and heat, fever, and multiple pulse disorders; (10) Sweating profusely, extremely weak, extremely tired, recovering from a serious illness, and emotionally unstable; (11) Other conditions that are not suitable for moxibustion treatment; (12) Other clinical trial participants who are currently participating in the evaluation of the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Digital Cancellation Test;Event-Related Potential-P300; | — |
Countries
China
Contacts
Public ContactLIN WANQING
The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine
Outcome results
None listed