Chemotherapy-induced peripheral neuropathy
Conditions
Interventions
Early Acupuncture Group:Under the same acupuncture manipulation conditions, the intervention time points were the 7th day, the 4th day, and the 1st day before the initiation of chemotherapy.
Delayed Acupuncture Group:Under the same acupuncture manipulation conditions, the intervention time points were on the 1st day, the 4th day, and the 7th day after the initiation of chemotherapy.
Waiting group:The "blank control" without acupuncture intervention, with the intervention measures being only "standardized medical care and observation procedures"
Sponsors
Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients newly diagnosed with stage II or III colorectal cancer (American Joint Committee on Cancer 8th edition staging); planning to receive oxaliplatin-based chemotherapy regimens (e.g., treatment course =6 cycles, oxaliplatin dose =85mg/m²); with an Eastern Cooperative Oncology Group performance status score of 0-1; who have signed informed consent forms, voluntarily participate in the study, and cooperate with bioelectric signal collection.
Exclusion criteria
Exclusion criteria: 1) Previous treatment with chemotherapy drugs such as paclitaxel, vinca alkaloids, and platinum-based agents (excluding oxaliplatin) that may cause chemotherapy-induced peripheral neuropathy; 2) Severe organ dysfunction (end-stage renal disease, severe heart failure) or uncontrolled infections; 3) Local infection, inflammation, or tumor infiltration at the acupuncture site; 4) Current use of antidepressants (e.g., duloxetine), antiepileptics (e.g., gabapentin), or neurotrophic drugs (e.g., mecobalamin); 5) Coagulation disorders ; 6) Use of non-removable electronic devices or metal implants (e.g., pacemakers); 7) Presence of consciousness disorders, psychiatric disorders, or communication impairments that prevent completion of scale assessments; 8) Pregnant or lactating women; 9) Concurrent diabetic peripheral neuropathy, HIV-associated neuropathy, or other severe non-chemotherapy-related neuropathies; 10) Receipt of any form of acupuncture or electroacupuncture within 30 days prior to enrollment. The most common symptom of hemorrhoids is painless bleeding during bowel movements..The most common symptom of hemorrhoids is painless bleeding during bowel movements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Chemotherapy-induced peripheral neuropathy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Chemotherapy-induced peripheral neuropathy at Week 2 and Week 4.;European Organisation for Research Quality of Life Questionnaire and Treatment of Cancer-Chemotherapy-Induced Peripheral Neuropathy 20-item scale score;European Organisation for Research and Treatment of Cancer score; | — |
Countries
China
Contacts
Public ContactYufeng Xie
Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine
Outcome results
None listed