Gastrointestinal Adverse Reactions Following Postoperative Chemotherapy for Colorectal Cancer
Conditions
Interventions
Intervention group:On the basis of FOLFOX chemotherapy patients in the intervention group will take the modified Huangqi Xianshu formula (comprising Astragalus membranaceus Codonopsis pilosula Poria c
control group:Treatment is administered according to the standard FOLFOX chemotherapy regimen, without the addition of Chinese herbal medicine.
Sponsors
Xiyuan Hospital of CACMS
Eligibility
Sex/Gender
All
Age
18 Years to 78 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with colorectal cancer who have undergone radical colorectal cancer surgery and are receiving chemotherapy one month postoperatively. Chemotherapy criteria: Stage II high-risk patients (T3N0M0 / pMMR with high-risk factors or T4N0M0) and all Stage III patients (any T N+ M0). 2. No use of microbial preparations (including foods containing lactic acid bacteria etc.) within the past two weeks. 3. No hematological diseases; systemic diseases such as cardiovascular cerebrovascular or metabolic disorders are in a stable condition. 4. Age between 18 and 78 years. 5. Clear consciousness and good compliance with treatment. 6. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of other malignant tumors or with metastasis. 2. Patients who underwent prophylactic or permanent stoma after surgery. 3. Patients with coexisting gastrointestinal or immune system diseases or severe organ dysfunction. 4. Individuals with specific dietary habits or irregular eating patterns. 5. Pregnant women. 6. Patients with psychiatric disorders. 7. Individuals who cannot tolerate oral Chinese herbal medicine. 8. Patients with incomplete data that may affect the assessment of outcomes or safety or those receiving other related treatments that could influence the study endpoints.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GSRS (Gastrointestinal Symptom Rating Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| Constipation and diarrhea assessment;Quality of life score ;Health status score ;Hematological parameters ;Liver and renal function;Nausea and Vomiting Score;Appetite Score;Cancer-Related Fatigue (CRF) Score;Urinalysis; | — |
Countries
China
Contacts
Public Contactxiezheninan
Xiyuan Hospital of CACMS
Outcome results
None listed