Uremic pruritus
Conditions
Interventions
Sponsors
Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine/Chengdu Pidu District Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Right-handed, 18 years old = age = 65 years old; (2) Meets the diagnostic criteria for end-stage renal disease and is accompanied by persistent itching symptoms for 6 weeks or more; (3) Has been regularly undergoing hemodialysis or hemofiltration treatment for more than 3 months; (4) The degree of itching is moderate to severe (average weekly score of 24-hour WI-NRS in the past week = 4 points, total score 10 points); (5) Within the first 3 months before enrollment, at least one single chamber urea clearance rate (spKt/V) of = 1.2 and urea decline rate (URR) of = 65%; (6) Not combined with serious mental illness or cognitive impairment; (7) Not combined with neurological diseases such as cerebral hemorrhage and cerebral infarction; (8) No addiction to alcohol or drugs; (9) Voluntarily participate in the research and provide written informed consent. Note: Only those who meet the above 9 criteria can be included.
Exclusion criteria
Exclusion criteria: (1) Patients with other skin diseases that can cause itching, such as psoriasis, atopic dermatitis, urticaria, contact dermatitis, etc; (2) Suffering from any severe chronic liver disease, or any one of alanine aminotransferase, aspartate aminotransferase, glutamyltransferase, or total bilirubin exceeding twice the upper limit of normal values; (3) Patients with malignant tumors or other serious illnesses that require hospitalization; (4) Individuals with severe mental illness or cognitive impairment (such as dementia); (5) During the research period, those who plan to undergo kidney transplantation or change their dialysis regimen to peritoneal dialysis; (6) Only those who experience itching during dialysis; (7) Individuals who have undergone physical therapy such as acupoint pressing, acupuncture, moxibustion, and phototherapy within one month to address itching symptoms; (8) Patients with coagulation dysfunction or local skin ulceration caused by acupuncture; (9) Individuals who have participated in another clinical study within the past six months and have been assessed by the researchers as potentially interfering with the evaluation of the results of this study, or who plan to participate in another clinical research during their participation in this study; (10) Pregnant or lactating women. Note: If any of the above conditions are met, it will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weekly average of 24-hour Worst Itch Numeric Rating Scale (24-hour WI-NRS);Cerebral functional network activity based on functional near-infrared spectroscopy(fNIRS); | — |
Secondary
| Measure | Time frame |
|---|---|
| 14-item uremic pruritus in dialysis patients scale;Dermatology Life Quality Index;General anxiety disorder;Patient Health Questionnaire-9; | — |
Countries
China
Contacts
Public ContactJie Chen
Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine/Chengdu Pidu District Traditional Chinese Medicine Hospital
Outcome results
None listed