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The Effect of Rhubarb on Severe Tetanus with Acute Gastrointestinal Injury

The Application of Rhubarb in Severe Tetanus Complicated with Acute Gastrointestinal Injury

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001839
Enrollment
Unknown
Registered
2025-09-26
Start date
2025-10-01
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Tetanus with Acute Gastrointestinal Injury

Interventions

Control group:ntravenous erythromycin (3 mg/kg, q8h)
Rhubarb group:Based on the intravenous erythromycin therapy, nasogastric administration of rhubarb is added: take 5g of raw rhubarb, decoct it using a machine, and filter to obtain 100 mL of medicinal

Sponsors

Jilin Province People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Meet the diagnostic criteria for tetanus(According to WHO standards, at least one of the following features must be present: trismus or risus sardonicus; painful muscular contractions), classified as Ablett grade III or IV; (2) Acute gastrointestinal injury (AGI) grade I; (3) Aged = 18 years and = 80 years; (4) Provide informed consent (from the patient or their legally authorized representative).

Exclusion criteria

Exclusion criteria: (1)Pregnant or lactating patients; (2) Patients with active gastrointestinal bleeding; (3) Patients with severe diarrhea; (4) Patients with known allergy to rhubarb.

Design outcomes

Primary

MeasureTime frame
Average daily AGI burden over 21 days;—

Secondary

MeasureTime frame
AGI duration;ICU length of stay ;Total length of stay;—

Countries

China

Contacts

Public ContactChunli Dong

Jilin Province People's Hospital

dongchunli33@163.com15948382477

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026