Parkinson's Disease
Conditions
Interventions
Qihuang needle + TMS group:Qihuang needle + TMS treatment + the basic treatment
TMS group:TMS and treatment
Qihuang needle group:Qihuang needle therapy and the basic treatment
Parkinson's basic medication group:maintain the original dose of medication
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 80 Years
Inclusion criteria
Inclusion criteria: (1) Diagnosed with Parkinson's disease according to internationally recognized diagnostic criteria; (2) Aged below 80 years; (3) Disease duration of at least 1 year; (4) Hoehn-Yahr stage between 1 and 4 (inclusive); (5) Receiving anti-parkinsonian medications with a stable dosage regimen maintained for at least 2 months; (6) Conscious with stable vital signs absence of significant cognitive impairment (MMSE =24) and no severe hearing impairment; (7) Provision of written informed consent.
Exclusion criteria
Exclusion criteria: (1) Secondary Parkinsonism or Parkinson-plus syndromes ; (2) Severe comorbid systemic diseases including significant hepatic/renal dysfunction hematologic disorders malignancies endocrine disorders or chronic pain conditions requiring active treatment; (3) Concurrent participation in other clinical trials involving pharmacologic or acupuncture interventions; (4) Active psychiatric disorders; (5) Severe hearing impairment or communication barriers precluding reliable assessment; (6) History of alcohol abuse (defined as >14 standard drinks/week for males >7 for females) or substance dependence (per DSM-5 criteria); (7) Individuals planning pregnancy currently pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| 39-Item Parkinson's Disease Questionnaire;Shear wave elastography;Quantitative analysis of the Synapsys Human Postural Balance System;Patient Assessment of Constipation Quality of Life;Cleveland clinic constipation score;levodopa equivalent daily doses;Spontaneous bowel movements;Bristol stool form scale;Gait Analysis;Blood(LBP);Blood(IL-6);Blood( IL-1ß);Blood( a-syn);intestinal microflora;short-chain fatty acids; | — |
Countries
China
Contacts
Public ContactChen Zhenhu
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed