Osteoporosis
Conditions
Interventions
normal group:none
Sponsors
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: ??Age Requirement??: =45 years old. ??Diagnostic Criteria (based on Dual-Energy X-ray Absorptiometry DXA)??: ??OP Group??: Lumbar spine bone mineral density (BMD) T-score = -2.5 (meeting diagnostic criteria for osteoporosis). ??Normal Group??: Lumbar spine bone mineral density (BMD) T-score > -1.0 (indicating normal bone density). ??Health Status??: Absence of severe cardiac hepatic or renal dysfunction. ??Medication and Medical History??: No other diseases affecting bone metabolism (e.g. thyroid disorders diabetes); No recent use of bone metabolism-related medications (e.g. bisphosphonates).
Exclusion criteria
Exclusion criteria: Inability to cooperate with follow-up or data collection. Any other condition not meeting the inclusion criteria (e.g. failure to satisfy age/diagnostic requirements without repeating specific inclusion criteria).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Core pathway indicators (CCN3 concentration, PI3K activity, phosphorylated Akt levels);Osteogenic function marker(Osteocalcin Concentration, Alkaline Phosphatase Activity);bone metabolism (bone mineral density (BMD)); | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation analysis (Pearson correlation coefficient (r value) between CCN3 and PI3K, Akt); Spearman rank correlation coefficient (? value) between CCN3 and osteogenic markers; Linear regression analysis (R ² value) of PI3K/Akt and bone density (T value);Significant difference between groups (mean difference test between 2 groups (independent sample t-test, p<0.05 is significant)); | — |
Countries
China
Contacts
Public ContactLin Xiaosheng
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine?
Outcome results
None listed