adolescent depression
Conditions
Interventions
Healthy Adolescent Group:none
" Wisdom Three Needles" Combined with Antidepressant Treatment Group:" Wisdom Three Needles"
Placebo Combined with Antidepressant Treatment Group:Placebo Combined with Antidepressant Treatment
Antidepressant Treatment Group:Antidepressant Treatment
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
10 Years to 24 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Adolescents with Depression: a. Recruited from the Psychology Clinic of the First Affiliated Hospital of Guangzhou University of Chinese Medicine; aged 10 to 24 years; b. Right-handed; c. Meet the diagnostic criteria for primary depression as defined in the Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5) and the International Classification of Diseases 10th Edition (ICD-10); d. Score >17 on the 17-item Hamilton Depression Scale (HAMD-17). Inclusion Criteria for Healthy Adolescents: a. Aged 10 to 24 years; b. Right-handed; c. Score =7 on the HAMD-17.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for Adolescents with Depression: a. Use of antidepressant treatment within 3 months prior to enrollment; b. History of other psychiatric disorders; c. History of neurological trauma or surgery; d. Presence of systemic diseases affecting the central nervous system or major organ diseases such as those involving the heart liver or kidneys; e. Secondary depressive episodes caused by other diseases; f. Contraindications to MRI scanning such as metal implants stents or pacemakers; g. Claustrophobia. Exclusion Criteria for Healthy Adolescents: a. History of neurological or psychiatric disorders including previous neurological trauma surgery or other neurological conditions; b. Presence of systemic diseases affecting the central nervous system or major organ diseases such as those involving the heart liver or kidneys; c. Contraindications to MRI scanning such as metal implants stents or pacemakers; d. Claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 17-HAMD SCALE; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood;MRI;Visual Search Task?;Flanker Task;Go/No-Go Task;Wisconsin Card Sorting Test;N-Back Task; | — |
Countries
China
Contacts
Public ContactLiu Yujie
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed