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Molecular mechanism and clinical study of Chuanxiong Scutellaria baicalensis Georgi and their compound in preventing and treating RP in chest tumor

Molecular mechanism and clinical study of Chuanxiong Scutellaria baicalensis Georgi and their compound in preventing and treating chest tumor RP in the upper reaches of the Yangtze River

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2025001744
Enrollment
Unknown
Registered
2025-09-15
Start date
2023-12-14
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung cancer esophageal cancer breast cancer

Interventions

Non-exposed group:Chest radiotherapy
Exposure group:Chest Radiotherapy Combined with Xiongqin Liujun Feikang Granules

Sponsors

Southwest medical university affiliated traditional Chinese medicine hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1) Lung cancer breast cancer and esophageal cancer diagnosed by cytopathology; 2) Age =18 years and =75 years weight = 40kg; 3) Subjects have not received immunotherapy in the past 3 months and will not consider immunotherapy within 6 weeks after entering the group; 4) The subject has no intention and the lung liver kidney and hematopoietic system are dysfunctional; The definition is as follows: the absolute value of neutrophils (ANC)=1.5×109/L; Platelets = 100× 109/L; Hemoglobin = 90g/L; Total bilirubin =1.5× upper normal limit (ULN); AST(SGOT)/ALT(SGPT)=2.5× normal upper limit; Serum albumin = 30g/L; Serum creatinine < 1.5 times the normal upper limit; 5) KPS score =60; 6) The estimated survival time is =3 months; 7) Fully understand this study and sign the informed consent form voluntarily.

Exclusion criteria

Exclusion criteria: 1) Prepare for tumor immunotherapy during radiotherapy; 2) Patients with unstable brain metastases; 3) Pregnant and lactating women and women of childbearing age who are unwilling to take contraceptive measures; 4) patients with mental illness or mental retardation; 5) It is known that the drug is severely intolerant; 6) In the past 4 weeks or participating in other clinical trials; 7) Complicating one of the following symptoms: uncontrollable hypertension (uncontrollable hypertension after single drug treatment that is systolic blood pressure > 160mmHg or diastolic blood pressure > 100mmHg after single drug treatment) severe arrhythmia and cardiac function grade III-IV (NYHA classification method). 8) Patients with respiratory failure pulmonary fibrosis massive pericardial effusion pleural effusion and pulmonary infection.

Design outcomes

Primary

MeasureTime frame
Cough, phlegm, fever, chest pain, wheezing, vomiting, diet, fatigue, nutrition;Tumor marker;Transforming growth factor ß1;Interleukin-6;Tumor necrosis factor-a;

Countries

China

Contacts

Public ContactLi Kuo

Southwest medical university affiliated traditional Chinese medicine hospital

312969183@qq.com15883017830

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026