Cognitive Impairment After Stroke
Conditions
Interventions
Sham-Electroacupuncture Group:Sham electroacupuncture and Shallow needling at non-acupoint sites
Electroacupuncture Group:Electroacupuncture
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Ischemic stroke diagnosis adhered to the 2019 AHA/ASA Guidelines for the Early Management of Patients With Acute Ischemic Stroke and Chinese Guidelines for Diagnosis and Treatment of Acute Ischemic Stroke 2023 requiring(1)acute onset; (2) focal(rarely global) neurological deficits; (3) neuroimaging evidence of a culprit lesion or symptoms/signs persisting >24 hours; (4) exclusion of non-vascular etiologies; and (5) absence of intracranial hemorrhage on CT/MRI. Cognitive impairment was diagnosed based on the *Expert Consensus on Management of Post-Stroke Cognitive Impairment 2021* using a Montreal Cognitive Assessment (MoCA) cut-off score of <26. Inclusion Criteria Participants must meet all of the following criteria to be eligible: 1.Fulfill the above diagnostic criteria; 2.Aged 18–75 years; 3.Ischemic stroke duration: 7–30 days; 4.MoCA <26 ability to complete assessments and cooperate with acupuncture; 5.Stable vital signs; National Institutes of Health Stroke Scale(NIHSS) score 1–15; 6.Signed informed consent by patient or legal guardian.
Exclusion criteria
Exclusion criteria: (1) Unstable vital signs or uncontrolled severe cardiopulmonary disease; (2) Previous stroke; (3) Pre-existing cognitive impairment, depression or other psychiatric disorders; (4) Malignancy, significant haematological disorder, respiratory failure or active infection; (5)Severe dysfunction of other organs or critical systemic diseases; (6) Severe visual/hearing impairments or aphasia precluding cooperation; (7) Imaging subgroup only: MRI contraindications (metallic implants/electronic devices) or left-handedness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Rating Scale; Hamilton Depression Rating Scale;functional Near-Infrared Spectroscopy;Mini-Mental State Examination;Modified Barthel Index;Pittsburgh Sleep Quality Index;Post-Stroke Cognitive Impairment Incidence;functional Magnetic Resonance Imaging; | — |
Countries
China
Contacts
Public ContactNingSun
West China Hospital of Sichuan University
Outcome results
None listed