Major depressive disorder
Conditions
Interventions
the control group:antidepressants
the acupuncture group:acupuncture combined with antidepressants
Sponsors
Shandong Daizhuang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 95 Years
Inclusion criteria
Inclusion criteria: a. Meets the diagnostic criteria for depressive disorders as outlined in the International Classification of Diseases (ICD-10) including first episode depression and recurrent depressive disorder with a clear diagnosis made using the MINI-International Neuropsychiatric Interview (M.I.N.I.); b. Aged 18 years or older; c. No gender restrictions; d. Have a certain level of education to understand the relevant scale content; e. A Hamilton Depression Rating Scale (HAMD) score of =20 and MADRS score of =28 before randomization; f. The patient or their guardian agrees to participate in this study.
Exclusion criteria
Exclusion criteria: a. Those who meet the diagnostic criteria for other mental disorders such as schizophrenia schizoaffective disorder bipolar disorder obsessive-compulsive disorder and depression caused by physical illnesses; b. Those who have received electroconvulsive therapy within the past 3 months; c. Female patients who are pregnant or breastfeeding; d. Those with serious physical illnesses or other conditions that affect acupuncture treatment; e. First-degree relatives with bipolar disorder; f. Those with significant suicide risk (MADRS item 10 = 5 points); g. Those with severe communication difficulties that prevent normal communication understanding or following instructions and cooperating with treatment and assessors; h. Situations deemed inappropriate for participation by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortisol;Montreal Cognitive Assessment;Activity of Daily Living Scale;the Hamilton Anxiety Rating Scale;Pittsburgh Sleep Quality Index;Montgomery-Asberg Depression Rating Scale;Symptom Checklist-90(SCL-90);Thyroid Function 5 Items;Adrenocorticotropic hormone;the Hamilton Depression Rating Scale;Cholinesterase; | — |
Countries
China
Contacts
Public ContactWANG ZHONGGANG
Shandong Daizhuang Hospital
Outcome results
None listed