Stage 3-4 Chronic Kidney Disease
Conditions
Interventions
Treatment Group:Conventional treatment + Fushen Granule
Control Group:Conventional treatment + 5% dosage of Fushen Granule
Sponsors
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-70 years regardless of gender;(2) Primary disease is chronic glomerulonephritis;(3) Conforms to Western medical diagnostic and staging criteria as well as TCM syndrome differentiation criteria;(4) Infections blood pressure (=140/90 mmHg) etc. are effectively controlled;(5) Has signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with acute renal failure;(2) Patients with secondary kidney diseases such as diabetic kidney disease hypertensive nephropathy Henoch-Schönlein purpura nephritis lupus nephritis etc.;(3) Patients with severe primary diseases of heart brain lung liver hematopoietic system and immune system;(4) Patients known to be allergic to this type of drugs or multiple drugs;(5) Pregnant or planning to become pregnant and lactating women;(6) Patients with mental illnesses who are unable to cooperate;(7) Patients who have participated in other clinical trials within 3 months before enrollment;(8) Patients who have used glucocorticoids and immunosuppressants (including Tripterygium glycosides tablets) within 3 months before enrollment;(9) Patients after kidney transplantation or scheduled for renal replacement therapy;(10) Patients with severe digestive diseases affecting drug absorption such as active ulcers chronic diarrhea gastrointestinal surgery etc.;(11) Patients who are determined by the researchers not to be enrolled for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glomerular Filtration Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Albumin;Quality of Life Score;High-Sensitivity C-Reactive Protein;Total Cholesterol;24-Hour Urine Protein Quantification;Blood Urea Nitrogen;Time to Endpoint Event and Incidence Rate;High-Density Lipoprotein;Traditional Chinese Medicine Syndrome Indicators;Fibrinogen;Triglycerides;Serum Uric Acid;Urine Albumin-to-Creatinine Ratio;Electrolytes;Total Protein;Low-Density Lipoprotein Cholesterol;Serum Creatinine; | — |
Countries
China
Contacts
Public ContactBo Yang
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed