Knee Osteoarthritis
Conditions
Interventions
Control Group:Health Education and Simplified Lower Limb Rehabilitation Training
Intervention group:Health Education and Simplified Lower Limb Rehabilitation Training and the three-step-six-style knee exercise
Sponsors
Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital or Fujian University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Aged 40-70 years regardless of gender Meets the diagnostic criteria for KOA Willing to undergo gait analysis blood tests and MRI examination Voluntarily participates and signs the informed consent form Kellgren-Lawrence (K-L) Grade I-III Unilateral knee osteoarthritis Body mass index (BMI) <28 kg/m²
Exclusion criteria
Exclusion criteria: Patients in acute phase of KOA (defined per Chinese Medicine Diagnosis and Treatment Guidelines for Knee Osteoarthritis (2020 Edition)): Knee pain with VAS score >7 Persistent pain severe enough to disrupt sleep Accompanied by knee swelling functional impairment limping or inability to ambulate Severe cognitive impairment or psychiatric disorders that may compromise assessment Comorbidities including: Rheumatoid arthritis Gout Osteoporosis Other relevant systemic diseases History of intra-articular injections or surgical interventions within the past 1 month Concurrent conditions affecting lower limb mobility or gait patterns
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Transient receptor potential vanilloid 4 (TRPV4):SRY-box transcription factor 9 (SOX9)Runt-related transcription factor 2 (RUNX2);Lower Limb Alignment Parameters;Visual Analog Scale Score;Serum Bone Metabolism Markers(ALP Rankl);MRI Score (WORMS);Gait Electromyography (EMG) Parameters;Kazam Classification;Gait Kinematic Parameters(Spatiotemporal gait parameters);Serum cartilage oligomeric matrix protein Serum type II collagen alpha-1 chain;Gait Kinetic Parameters;Meniscus load distribution Tibial/femoral cartilage load distribution Joint contact forces;Gait Kinetic Parameters; | — |
Countries
China
Contacts
Public ContactGuo Jiemei
Rehabilitation Hospital or Fujian University of Chinese Medicine
Outcome results
None listed