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Observation and Mechanistic Investigation of Xiaozhong Kuijian Decoction Administered Orally and Topically on Postoperative Wound Healing in High Perianal Abscess: A Prospective Single-Blind Randomized Controlled Trial

Observation and Mechanistic Investigation of Xiaozhong Kuijian Decoction Administered Orally and Topically on Postoperative Wound Healing in High Perianal Abscess: A Prospective Single-Blind Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001554
Enrollment
Unknown
Registered
2025-08-14
Start date
2024-04-30
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Perianal Abscess

Interventions

Oral Group:Oral administration of XZKJD group. Patients took one dose per day of the XZKJD divided into three oral administrations of 200 ml each. Following routine disinfection during daily dressing
Control group:Patients in this group received routine normal saline irrigation and dressing changes, with no oral or topical fumigation of herbal medicine. Similar to the other groups, a 50 ml syringe
Topical Fumigation Group:Patients underwent topical fumigation with XZKJD for irrigation and dressing changes, with no oral intake of the herbal medicine. Following routine disinfection during daily d

Sponsors

Hospital of Chengdu University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1) Patients diagnosed with high grade perianal abscess (the diagnosis is heat-toxin-containing knot syndrome) and undergoing surgery for virtual and real hanging wire (multi-incision floating wire drainage); 2) Age between 18 and 60 years old; 3) Blood urine feces routine bleeding and coagulation time liver and kidney function blood glucose electrocardiogram are within the normal range; 4) Normal cognitive function with basic communication and exchange ability; 5) Good compliance to the researcher's observation and treatment Voluntary Participate in the clinical observation trial and sign the consent form; 6) Voluntarily participate in this project and sign the informed consent form.

Exclusion criteria

Exclusion criteria: The existence of any one of the following conditions are excluded: 1) tuberculosis leukemia trauma immune diseases Crohn's disease and inflammatory bowel disease and other specific perianal abscess; 2) combined with systemic diseases such as malignant neoplasms diabetes mellitus severe hypertension hematological system and other primary diseases; 3) combined with gastrointestinal disorders such as chronic constipation chronic diarrhea etc.; 4) serious heart brain liver lungs kidneys and other important organ diseases and mental illnesses; 5) combined with other anal diseases such as rectal prolapse anal eczema rectal polyps etc.; 6) previous patients with heart brain liver lung kidney and other major organ diseases and mental illnesses; 5) combined with other anal diseases such as prolapsed rectum Patients with severe heart brain liver lung kidney and other important organ diseases and mental diseases; 5) patients with other anal diseases such as rectal prolapse anal eczema rectal polyps etc.; 6) patients with a history of anal surgery or abnormal anal morphology and function; 7) patients with infectious diseases such as tuberculosis hepatitis B sexually transmitted diseases etc.; 8) women in pregnancy or breastfeeding; 9) patients who participate in other clinical experimental research.

Design outcomes

Primary

MeasureTime frame
IL-6(Interleukin 6);IL-1ß(Interleukin 1 beta);TNF-a(Tumor Necrosis Factor-alpha);

Secondary

MeasureTime frame
Wound secretion;Wound healing;pain in the wound;

Countries

China

Contacts

Public ContactHao Fu

Hospital of Chengdu University of Traditional Chinese Medicine

xjhgcyjs@126.com13550154776

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026