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Research on the regulation of oral microecological balance and antimicrobial peptide LL-37-related inflammatory circuit in patients with palmoplantar pustulosis by dehumidification and detoxification

Observation on the efficacy of dehumidification and detoxification method in the treatment of palmoplantar pustulosis: a self-controlled before-after study based on oral microecological balance and antimicrobial peptide LL-37-related inflammatory circuit

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001530
Enrollment
Unknown
Registered
2025-07-30
Start date
2022-10-27
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Palmoplantar pustulosis

Interventions

Chinese Medicine Group:Qingpao Chushi Jiedu Formula (QCJF) for oral use
Health Control Group:without any intervention

Sponsors

No. 5 Beixiange Guang'anmen Nei Avenue Xicheng District
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1. Patients who meet the Western medical diagnosis criteria for palmoplantar pustulosis; 2. Patients who meet the Chinese medical diagnosis criteria for palmoplantar pustulosis; 3. Age = 18 years old; 4. Patients who have given informed consent

Exclusion criteria

Exclusion criteria: 1. Individuals under the age of 18; 2. Individuals afflicted with severe cardiac hepatic renal hematological digestive endocrine and other systemic ailments in addition to dermatological conditions are also included. 3. Women who are pregnant and women who are lactating 4. Individuals with documented allergies to specific components of the therapeutic or control drug should be considered. 5. Individuals who have ingested oral retinoids immunosuppressants tetracyclines glucocorticoids or other pharmaceutical agents for the treatment of this disease within the past month are included in this study. 6. Individuals who are currently utilizing topical hormones or physical therapy as treatment for this condition.

Design outcomes

Primary

MeasureTime frame
Skin Lesion Score;

Secondary

MeasureTime frame
Itch/pain score;Quality of life score;

Countries

China

Contacts

Public ContactWang Junhui

Guang'anmen Hospital China Academy of Chinese Medical Sciences

747191432@qq.com13264396702

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Jul 5, 2026