atherosclerosis
Conditions
Interventions
control group:conventional therapy
experimental group:Guanxingshu Pill
Sponsors
Shiyan Hospital of Traditional Chinese Medicin
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: This study aims to clarify the mechanism by which the coronary heart relief formula (mediated by IL-18) regulates macrophage autophagy to control coronary heart disease based on clinical RCT technology. The study expects to reveal that taking the coronary heart relief formula can effectively prevent and treat chronic coronary syndrome clarify its application value in chronic coronary syndrome and provide a reference for the diagnostic criteria of chronic coronary syndrome in traditional Chinese medicine Western medicine and Chinese medicine. According to the "Chinese Guidelines for Diagnosis and Management of Chronic Coronary Syndrome" (2024 edition) it includes other stages of coronary heart disease evolution such as stable angina pectoris ischemic cardiomyopathy hospitalization due to acute coronary syndrome or coronary artery revascularization and subsequent stable discharge vasospasm or microvascular angina and asymptomatic coronary artery disease. Traditional Chinese medicine diagnostic criteria: The diagnostic criteria for the syndrome of chest pain due to intermingled blood stasis and phlegm in coronary heart disease can refer to the "Diagnostic Criteria for Syndrome Elements of Coronary Heart Disease Angina Pectoris" and the "Diagnosis Criteria for Main Syndromes of Coronary Heart Disease Angina Pectoris". 1) Blood stasis: Fixed chest pain score of 4 points Purple and dark tongue or tongue with blood stasis spots score of 4 points Purple and dark veins under the tongue score of 3 points Dark complexion score of 3 points Body with blood stasis spots or bruises score of 3 points Limb numbness score of 2 points Dark and red lips score of 2 points Taut pulse score of 2 points. 2) Phlegm turbidity: Chest tightness and pain score of 3 points Excessive phlegm and obesity score of 3 points Enlarged and thick tongue coating score of 3 points Mucous and sticky stool score of 2 points Limb heaviness score of 2 points Headache and excessive sleepiness score of 2 points Dry and unsatisfactory mouth score of 2 points Sliding pulse score of 2 points. Scoring method: 1) A total score of =8 points for a single syndrome element can lead to a diagnosis; 2) A diagnosis can be made if both syndrome elements of blood stasis and phlegm turbidity are met; 3) If neither of the syndrome elements of blood stasis and phlegm turbidity is met a non-tumor intermingled blood stasis and phlegm turbidity diagnosis can be made. Inclusion criteria 1) Those who meet the above diagnostic criteria of both traditional Chinese and Western medicine; 2) 18-75 years old gender not limited; 3) Sign the "Informed Consent Form" voluntarily participate in this study and be able to cooperate with the requirements of follow-up and examination.
Exclusion criteria
Exclusion criteria: 1) Those who have suffered from myocardial infarction or undergone coronary artery revascularization surgery within the past year; 2) Patients with other heart diseases neurosis menopause syndrome hyperthyroidism and other diseases that may cause chest pain; 3) Those with severe liver or kidney dysfunction; 4) Those with severe primary diseases such as respiratory hematological or malignant tumors; 5) Pregnant women lactating women or women of childbearing age with fertility requirements; 6) Patients with mental disorders; 7) Those with poor compliance and unable to follow up regularly; 8) Those with allergic constitution and a history of allergic reactions to traditional Chinese medicine; 9) Other situations that the researcher considers as not suitable for participating in this study. 10) Those with a heart rate less than 50 beats per minute combined with sick sinus syndrome second-degree and second-degree or higher atrioventricular block; 11) Those with atrial fibrillation or atrial flutter; 12) Those with acute attacks of bronchial asthma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electrocardiogram;interleukin-18; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCM syndrome score;CompleteBloodCount;Evaluation criteria for the therapeutic effect of angina pectoris;Family history of cardiovascular and cerebrovascular diseases;The incidence of angina pectoris and cardiovascular events;Coagulation function;past medical history;gender;age;Renal function;Result of coronary angiography;Body Mass Index;Liver function; | — |
Countries
china
Contacts
Public ContactJia Luyang
Hubei University of Chinese Medicine
Outcome results
None listed