Septic Shock
Conditions
Interventions
Treatment group:Oral administration of Pogejixin Decoction was administered in addition to conventional Western medical treatment.
Control group:Empirical antibiotic therapy as well as fluid resuscitation and vasopressor administration for symptomatic management.
Sponsors
Foshan Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1)Patients who meet the diagnostic criteria for septic shock;(2)Aged 18 to 80 years;(3)Patients who are diagnosed with Yang Qi deficiency and collapse or Yin depletion with Yang collapse according to Traditional Chinese Medicine (TCM) differentiation;(4)The research content must be reviewed and approved by the Medical Ethics Committee of our hospital. Only those patients who have provided informed consent either by themselves or through their family members and have signed the consent form are eligible.
Exclusion criteria
Exclusion criteria: (1)Individuals who do not meet the inclusion criteria fail to follow the prescribed medication regimen or have incomplete data that affects the assessment of therapeutic efficacy; (2)Patients with gastrointestinal perforation or severe gastrointestinal dysfunction with a gastrointestinal function score of 3 who are unable to receive enteral medications; (3)Patients with acute or chronic renal failure requiring continuous blood purification;(4)Patients with severe underlying diseases such as cardiomyopathy acute myocardial infarction massive pulmonary embolism acute cerebrovascular accident or Stage IV malignant tumors;(5)Pregnant women or those who have been taking immunosuppressive agents long-term or those who require high-dose corticosteroids due to their medical condition;(6)Patients or their family members who do not agree.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of Stay;Vascular Endothelial Growth Factor(VEGF);Nitric Oxide(NO);Lactate(Lac);Soluble Thrombomodulin(sTM);Heart Rate(HR);6-Keto-Prostaglandin F1a(6-keto-PGF1a);Daily Fluid Requirement;Blood Pressure(BP);Daily Vasopressor Dosing;SOFA Score;APACHEII Score;Endothelium-Derived Relaxing Factor(EDRF);28-Day Mortality Rate;Duration of Vasopressor Therapy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Procalcitonin(PCT);White Blood Cell Count(WBC);Neutrophil Percentage(NEUT%); | — |
Countries
China
Contacts
Public ContactQiusheng Xiao
Foshan Hospital of Traditional Chinese Medicine
Outcome results
None listed