LUNG CANCER
Conditions
Interventions
control group:Routine Western medical management such as tetracycline minocycline or roxithromycin may be applied topically 1–3 times daily without restriction. The placebo consists of 5 % of the orig
experimental group:blood-cooling and detoxification formula+Routine Western medical management such as tetracycline minocycline or roxithromycin may be applied topically 1–3 times daily without restri
Sponsors
Beijing Shijitan HospitalCapital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing EGFR-TKIs targeted therapy for IIIB and stage IV NSCLC (2) Patients who meet the diagnostic criteria for acne-like rash associated with EGFR-TKIs therapy with rash grade =1 (3) Patients with blood-heat and toxin-containing symptoms (4) Aged 18-80 years (5) Expected survival = 3 months KPS functional status score = 70 points (6) Subjects without major organ dysfunction such as severe heart liver and kidney impairment or serious primary diseases (7) Good compliance and signing of informed consent before enrollment
Exclusion criteria
Exclusion criteria: (1) Subjects with known or suspected hypersensitivity to known components of the study drug (2) Subjects with intestinal obstruction that cannot be treated with oral medication requiring intravenous high-energy nutrition or suffering from severe malabsorption or other diseases that affect absorption in the gastrointestinal tract. (3) Those who are unable to understand read and fill in the patient self-assessment scale due to their knowledge or intelligence. (4) Pregnant and lactating women (5) Combination of other skin diseases such as eczema psoriasis atopic dermatitis etc. The researcher decides that they are not suitable to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Effective Rate of Rash; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cytokine Assay;Dermatology Life Quality Index (DLQI) and Karnofsky Performance Status (KPS);Immune Function Testing;Traditional Chinese Medicine Syndrome Score; | — |
Countries
China
Contacts
Public ContactJiang Min
Beijing Shijitan HospitalCapital Medical University
Outcome results
None listed