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The process of decidualization in PCOS regulated by acupuncture was studied based on the HIF1a -glycolytic -H4K12 lactation feedback loop Improve the mechanism of action of embryo implantation

The process of decidualization in PCOS regulated by acupuncture was studied based on the HIF1a -glycolytic -H4K12 lactation feedback loop Improve the mechanism of action of embryo implantation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001485
Enrollment
Unknown
Registered
2025-07-26
Start date
2025-08-02
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovarian syndrome

Interventions

Acupuncture at the eight acupoints around the umbilicus:Acupuncture is performed at eight points around the umbilicus

Sponsors

The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Age: 20-40 years old; 2. Meet the diagnostic criteria for PCOS; 3. Meet the diagnostic criteria for insulin resistance; 4. The fallopian tube patency test in the past three years shows that at least one fallopian tube is unobstructed. 5. The husband's semen analysis is normal. 6. The subjects voluntarily participated and signed the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Combined with other reproductive system diseases. 2. Concurrent with other endocrine diseases. 3. Those with serious primary diseases in internal medicine surgery psychiatry etc. 4. Patients who have used other drugs known to affect reproductive function or metabolic levels. 5. Patients who currently have a history of alcohol abuse. 6. Have experienced weight loss through medication or dieting within the last three months. 7. Acupuncture treatment for this disease has been received in the last three months. 8. History of pregnancy miscarriage and childbirth within the last 6 weeks. 9. Breastfeeding within the last six months. 10. There are other diseases that affect pregnancy.

Design outcomes

Primary

MeasureTime frame
live birth rate;

Secondary

MeasureTime frame
Serum free testosterone;Cycle ovulation rate;The level of sex hormone-binding globulin;Multiple pregnancy rate;Complications during pregnancy;Ongoing pregnancy rate;gonadal hormone concentrations;Four items of blood lipid;Positive rate of HCG;Glycated hemoglobin concentration;first trimester abortion rate;Psychological state and quality of Life scale scores;clinical pregnancy rate;Glucose tolerance and insulin release test;

Countries

China

Contacts

Public ContactZhen Dou

Tianjin University of Traditional Chinese Medicine

dz-0820@126.com15022754480

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026