Mild cognitive impairment
Conditions
Interventions
healthy controls group:No intervention will be administered
sham taVNS group:sham transcutaneous auricular vagus nerve stimulation
Sponsors
National Natural Science Foundation of China
Eligibility
Sex/Gender
All
Age
50 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1: Self-awareness or family confirmation of cognitive decline but the daily life function is basically normal did not reach dementia that is the Minimum mental state examination (MMSE) score: illiteracy >17; Primary level >20 secondary level (including technical secondary school) >22; University degree (including junior college) >23; 2: Meeting Jak/Bondi diagnostic criteria; 3: Age 50-79 years old right-handed; 4: The score of Montreal cognitive assessment-basic (MoCA-B) is lower than the corresponding educational level standard that is the score of primary school is =19; Middle school score =22; University and above score =24); 5: Magnetic resonance imaging showed no serious brain parenchymal lesions; 6: Voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1: Self-awareness or family confirmation of cognitive decline but the daily life function is basically normal did not reach dementia that is the Minimum mental state examination (MMSE) score: illiteracy >17; Primary level >20 secondary level (including technical secondary school) >22; University degree (including junior college) >23; 2: Meeting Jak/Bondi diagnostic criteria; 3: Age 50-79 years old right-handed; 4: The score of Montreal cognitive assessment-basic (MoCA-B) is lower than the corresponding educational level standard that is the score of primary school is =19; Middle school score =22; University and above score =24); 5: Magnetic resonance imaging showed no serious brain parenchymal lesions; 6: Voluntarily sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Parameters;Animal Fluency Test ;Montreal Cognitive Assessment-basic;Functional magnetic resonance imaging indicators;Bostion Naming Test;Shape Trails Test A&B;Functional Activity Questionnaire;Resting-state EEG indicators;Auditory Verbal Learning Test-Huashan Verision; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;17-item Hamilton Depression Scale;Pittsburgh Sleep Index; | — |
Countries
China
Contacts
Public ContactJiliang Fang
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed