Skip to content

To observe the clinical efficacy and mechanism exploration of autologous blood acupoint injection in the treatment of allergic rhinitis based on the NLRP3/caspase-1/GSDMD/IL-1ß pathway

To observe the clinical efficacy and mechanism exploration of autologous blood acupoint injection in the treatment of allergic rhinitis based on the NLRP3/caspase-1/GSDMD/IL-1ß pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001449
Enrollment
Unknown
Registered
2025-07-20
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Allergic rhinitis

Interventions

Autologous blood acupoint injection group:Autologous blood injection at acupoints
Fake acupoint and fake injection treatment group:False acupoint and false injection treatment
Acupoint injection of normal saline group:Inject normal saline at acupoints

Sponsors

Chengdu University of Traditional Chinese Medicine Affiliated Hospital Jinniu District Chengdu City Sichuan Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1) Meet the above diagnostic criteria 2) Age: 18 to 70 years old (inclusive) gender not limited; 3) Those who have the ability to understand the nature of the research agree to participate in this trial and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1) Those with concurrent otorhinolaryngological infections or organic lesions such as sinusitis otitis media nasal polyps and deviated nasal septum; 2) Under 18 years old or over 70 years old; 3) Pregnant or lactating women; 4) Those with severe primary diseases such as cardiovascular liver kidney and hematopoietic system diseases mental patients and serious diseases that affect their quality of life; 5) Those who have used antihistamines or corticosteroids within the past month or received traditional Chinese acupuncture treatment or other related treatments that affect the judgment of therapeutic effects.

Design outcomes

Primary

MeasureTime frame
Rhinoconjunctivitis Quality of Life Questionnaire;Total Nasal Symptom Score;Physical sign score;Total Non-nasal Symptom Score;

Secondary

MeasureTime frame
Serum IL-10;NLRP3 in nasal mucosa tissue;Serum IL-1ß;Serum IgE;caspase-1 in nasal mucosa tissue;GSDMD in nasal mucosa tissue;

Countries

China

Contacts

Public ContactPengShunlin

Affiliated Hospital of Chengdu University of Traditional Chinese Medicine

726576233@qq.com18980880161

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026