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Mechanistic Study on How the Wenyang Huazhuo Formula Modulates Intercellular Communication in Endometrial Cells During Embryo Implantation by Targeting Macrophage Polarization Through the JAK/STAT1 Axis

Mechanistic Study on How the Wenyang Huazhuo Formula Modulates Intercellular Communication in Endometrial Cells During Embryo Implantation by Targeting Macrophage Polarization Through the JAK/STAT1 Axis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001448
Enrollment
Unknown
Registered
2025-07-20
Start date
2026-01-01
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic endometritis

Interventions

The Chinese herbal medicine placebo group (antibiotics combined with Chinese herbal medicine placebo):antibiotic (Doxy Cyclin 100mg, twice daily, combined with metronidazole 0.4g, 3 times daily for 14
Chinese Medicine Group (Antibiotics Combined with Wenyang Huazhuo Granules):Antibiotics (Doxycycline 100 mg twice daily + Metronidazole 0.4 g three times daily for 14 days)

Sponsors

Weifang Hospital of Traditional Chinese Medicine Weifang City Shandong Province China
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: (A) Aged between 20–40 years; (B) Diagnosed with infertility and chronic endometritis (CE) based on established criteria; (C) Presenting with TCM pattern differentiation of spleen-kidney yang deficiency (); (D) At least one patent fallopian tube (confirmed by hysterosalpingography or laparoscopy); (E) Willing to participate and able to provide signed informed consent.

Exclusion criteria

Exclusion criteria: (A) Comorbid reproductive system disorders such as: Infertility due to ovulatory dysfunction Endometriosis Intrauterine adhesions (Ashermans syndrome) Uterine fibroids (leiomyoma) Uterine malformations (e.g. septate uterus) Hydrosalpinx (B) Diagnosed endocrine or immune diseases including: Polycystic ovary syndrome (PCOS) Thyroid dysfunction (hypo-/hyperthyroidism) Autoimmune disorders (e.g. antiphospholipid syndrome) (C) Severe systemic diseases such as: Uncontrolled cardiovascular hepatic or renal diseases Acute infectious diseases Psychiatric disorders requiring medication Malignancies or active tumors (D) Male partner with azoospermia (confirmed by semen analysis). (E) Genetic disorders (in either partner) that may affect pregnancy outcomes. (F) Known allergy to any component of Wenyang Huazhuo Formula.

Design outcomes

Primary

MeasureTime frame
Live Birth Rate ;—

Secondary

MeasureTime frame
late miscarriage rate, preterm labor rate;clinical pregnancy rate;expired pregnancy rate;biochemical pregnancy rate;and birth defects rate;early miscarriage rate;ncidence of obstetric complications;birth rate of macrosomic babies;preterm labor rate;birth rate of low-body-mass babies;persistent pregnancy rate;—

Countries

China

Contacts

Public ContactWuChunlei

Weifang Hospital of Traditional Chinese Medicine Weifang City Shandong Province China

18222515187@163.com+86 182 2251 5187

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026