Knee osteoarthritis
Conditions
Interventions
Medical Exercise Therapy Group (MET):Muscle strength training\Modified Three-Step Nine-Method Protocol
Celecoxib Group (CLB):Oral celecoxib administration
Integrative EA-Exercise Group (IZ-EA+TSNM):Electroacupuncture at innervation zonesIntegrated Three-Step Nine-Method Protocol combined with muscle training
Innervation Zone Electroacupuncture Group (IZ-EA):Electroacupuncture stimulation at innervation zones
Sponsors
Huadong Hospital Fudan University
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Diagnosis of early-stage knee osteoarthritis (KOA) conforms to the Guidelines for Diagnosis and Non-surgical Treatment of Early Knee Osteoarthritis (2024 Edition) (Chinese Medical Journal 2024 104(31)):Aged >60 years with unilateral lower limb KOA; 2) Knee pain lasting >1 month; 3) Joint stiffness =30 minutes; 4) Presence of crepitus (sensation) or joint space tenderness during movement; 5) Weight-bearing (standing) X-ray shows:No obvious changes in the joint or osteophytes and/or questionable joint space narrowing (Kellgren-Lawrence grade 0–?); 6) Good patient compliance to complete treatment and follow-up; 7) Informed consent form signed.
Exclusion criteria
Exclusion criteria: 1)Severe varus or valgus deformity of the knee joint. 2)Patients with a history of joint replacement; those who have received intra-articular injection of chondroprotective agents or pus aspiration within 4 months. 3)Those who have received analgesic treatment within 1 month. 4)Patients complicated with malignant or autoimmune diseases. 5)Patients complicated with other bone diseases such as knee joint tuberculosis tumors rheumatic arthritis and rheumatoid arthritis etc. which do not belong to osteoarthritis. 6)Patients with lesions such as ankle and foot deformities and calcaneal pain that affect normal walking. 7)Other cases unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Test of balance;Visual Analog Scale;Analysis of gait;High density electromyography;Muscle strength testing;Clinical efficacy; | — |
Countries
China
Contacts
Public Contactxuguohui
Huadong Hospital Fudan University
Outcome results
None listed