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Acupuncture for Diminished Ovarian Reserve: A Multicenter Randomized Controlled Trial

Acupuncture for Diminished Ovarian Reserve: A Multicenter Randomized Controlled Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001400
Enrollment
Unknown
Registered
2025-07-14
Start date
2025-06-01
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diminished Ovarian Reserve

Interventions

Sham Acupuncture Group:Sham Acupuncture
Acupuncture Group:Acupuncture

Sponsors

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
19 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1) Age between 19-40 years with history of sexual activity; 2) Meeting Western medicine diagnostic criteria for Diminished Ovarian Reserve (DOR); 3) Meeting Traditional Chinese Medicine (TCM) diagnostic criteria for kidney deficiency with blood stasis syndrome; 4) Patients provided informed consent and voluntarily participated in the study.

Exclusion criteria

Exclusion criteria: 1) Patients with other endocrine diseases affecting ovarian function (e.g. endometriosis polycystic ovarian syndrome thyroid disorders hyperprolactinemia adrenal tumors) or organic lesions of reproductive organs; 2) Patients with DOR caused by genetic factors or iatrogenic factors (e.g. uterine artery embolization radiotherapy/chemotherapy or immunosuppressants); 3) Patients who received DOR-related medications or complementary therapies (including acupuncture Chinese herbal medicine proprietary Chinese medicines or complementary and alternative medicine therapies) within the past 8 weeks; 4) Patients who used hormonal drugs or medications affecting reproductive endocrinology/metabolism within the past 12 weeks; 5) Patients with organic lesions in vital organs (heart lungs liver kidneys) hematologic diseases malignant tumors psychiatric disorders or other conditions preventing cooperation with the trial; 6) Patients currently undergoing other treatments or participating in other clinical trials; 7) Patients with contraindications to acupuncture (e.g. use of anticoagulant medications valvular heart disease poorly controlled diabetes mellitus).

Design outcomes

Primary

MeasureTime frame
FSH;—

Secondary

MeasureTime frame
LH;AIFM1;AFC;mtDNA;mtROS;Ang-1;VEGF;AMH;S/D;ATP;MDA;EDV;Mitochondrial morphology;PGAM5;TCM syndrome score;??m;Ang-2;KEAP1;mtPGC-1a;PSV;PI;HIF-1a;Mitochondrial superoxide;Granular cell death profile;PSV;E2;SOD;GSH-Px;RI;ROS;menstrual cycle;—

Countries

China

Contacts

Public ContactYan Ying

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

yanying799@163.com18622662859

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026