Dry eye
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) meet the diagnostic criteria of dry eye; At the same time it was accompanied by ocular pain > dryness burning sensation foreign body sensation and one of the symptoms of ocular surface neuralgia. (2) age >18 years old <40 years old (3) Anesthetic treatment was effective (4) no other active inflammation except dry eye no serious cardiovascular cerebrovascular and systemic diseases; (5) no other treatment or medication was taken during the treatment period; (6) Informed consent was signed
Exclusion criteria
Exclusion criteria: (1) patients with eye pain caused by other diseases such as glaucoma herpes zoster (2) dry eye treatment using methods other than those used in this study (3) abnormal corneal sensation (4) history of ocular surgery or trauma within 6 months (5) contact lens wearing history within 1 month (6) complicated with other underlying diseases requiring long-term medication or serious systemic diseases (7) pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-17Ainflammatory factor in tears;Corneal nerve length;IL-8 inflammatory factor in tears;The number of corneal immune cells;IL-9 inflammatory factor in tears;Corneal nerve branch density;MM-9 in the tear;Corneal nerve tortuosity;Corneal nerve density; | — |
Secondary
| Measure | Time frame |
|---|---|
| BUT;NPSI-EYE;OSDI;ST;FL;DEQS; | — |
Countries
China
Contacts
Staff and workers