Atherosclerotic plaque
Conditions
Interventions
Experimental group:CS001 capsule, 4 capsules at a time, 3 times/day
Sponsors
School of Public Health, Zhejiang Chinese Medicine University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) The ultrasound diagnostic criteria for carotid atherosclerotic plaque were met; (2) Conforming to the diagnosis of TCM syndromes and accompanied by relevant clinical symptoms in TCM. (3) Age 18-75 years old (including 18 years old and 75 years old) male or female; (4) Bilateral or unilateral carotid atherosclerotic lesions; (5) intima-media thickness (IMT)=1.2mm; (6) Carotid ultrasound diagnosis of mild to moderate stenosis (<70%) plaque stability and no surgical intervention; (7) Sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with atherosclerotic diseases have been diagnosed including coronary heart disease stroke peripheral vascular disease renal artery stenosis etc.; (2) Subjects with hemoglobin 7.8mmol/L LDL-C>5.0mmol/L); (12) Patients with severe hypertension and poor blood pressure control after intervention treatment (=160/90mmHg); (13) Heart failure and severe arrhythmia (persistent rapid atrial fibrillation atrial flutter frequent ventricular premature ventricular tachycardia second degree or more atrioventricular block); (14) Liver function AST ALT > 2N (N is the upper limit of normal value); Serum creatinine (Scr) > 176umol/L; (15) Patients with a life expectancy of less than 1 year; (16) Subjects with intellectual disability or mental illness who are unable to cooperate; (17) People who are allergic or allergic to the experimental drug (allergic to two or more foods or drugs); (18) Women who are pregnant breastfeeding and preparing to become pregnant;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carotid plaque thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence rate of cardiovascular and cerebrovascular events;Narrowing rate of the lumen;Plaque stability;The therapeutic effect of individual TCM syndromes;The average intima-media thickness of the carotid artery (the average value of the inner middle layer of the carotid artery at 1 cm and 2 cm from the bifurcation of the common carotid artery on both sides and 1 cm from the bifurcation of the internal carotid artery on both sides);Curative effect of TCM syndrome;Lipid change;Carotid plaque area; | — |
Countries
china
Contacts
Public Contactwang hongyang
School of Public Health Zhejiang Chinese Medicine University
Outcome results
None listed