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Exploring the Analgesic Efficacy and Mechanism of Wrist-Ankle Acupuncture in Postherpetic Neuralgia via Modulation of Pain-Related Ion Channels NaV1.7

Exploring the Analgesic Efficacy and Mechanism of Wrist-Ankle Acupuncture in Postherpetic Neuralgia via Modulation of Pain-Related Ion Channels NaV1.7

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001389
Enrollment
Unknown
Registered
2025-07-11
Start date
2024-02-05
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postherpetic neuralgia

Interventions

Control group:5% lidocaine gel patch
Test group:Wrist-ankle acupuncture

Sponsors

The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Patients meets the diagnostic criteria of PHN and the affected area is located in the thoracic and costal regions or the waist and abdomen. (2) Age 50-75 years old male or female and the disease course is = 12 months; ?(3) 4 points = Visual Analogue Scale (VAS) score = 8 points; ?(4) No medication or other treatment methods have been taken for PHN in the past two weeks;Not participating in other ongoing clinical studies; (5) The patient agreed to participate in this study signed the informed consent form and was able to cooperate in completing various evaluations and interventions.

Exclusion criteria

Exclusion criteria: (1) Some special types of herpes zoster patients, such as PHN patients caused by perineum, generalized herpes zoster, etc; (2) Patients who take relevant analgesic drugs before enrollment, are unwilling to undergo elution, or have serious safety issues during elution or observation period. Patients who have undergone nerve intervention surgery or other neurosurgical treatments for PHN; (3) Those with damaged skin in the painful area; Individuals with a history of allergy to amide local anesthetics and those who are allergic to the investigational drug; (4) Individuals who have used glucocorticoids or immunosuppressants within one month; Pathological neuralgia due to other reasons (such as diabetes, trigeminal neuralgia, etc.) and cancer pain patients; (5) Patients currently taking Class I antiarrhythmic drugs (i.e. lidocaine, metoprolol, phenytoin sodium, etc.); (6) Patients with combined systemic infections, severe heart, liver, kidney, blood and other systemic diseases, or malignant tumors; Or combined with coagulation dysfunction; (7) Patients with mental illnesses, such as severe anxiety and depression; Individuals with a history of opioid or tranquilizer drug abuse.

Design outcomes

Primary

MeasureTime frame
Visual analogue scale;

Secondary

MeasureTime frame
Dermatology life quality index;Self-rating anxiety scale;Pittsburgh sleep quality index;Self-rating depression scale;

Countries

China

Contacts

Public ContactWeiqun Liu

The Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine

1350441369@qq.com18065148322

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026