Generalized anxiety disorder
Conditions
Interventions
positive control group:sertraline or escitalopram oxalate tablets
experimental group:Acupuncture combined with sertraline or escitalopram oxalate tablets
Placebo control group:Sham acupuncture combined with sertraline or escitalopram oxalate tablets
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 44 Years
Inclusion criteria
Inclusion criteria: 1)Meet diagnostic criteria for Generalized Anxiety Disorder (GAD) and Insomnia Disorder according to both Traditional Chinese Medicine (TCM) and Western medicine standards. 2)Aged 18-44 years both genders eligible. 3)Baseline scores meeting: GAD-7 (Generalized Anxiety Disorder-7): 10-14 points ISI (Insomnia Severity Index): =8 but 5 but <16 points 4)Voluntarily participate in the study by signing informed consent and able to adhere to acupuncture therapy and/or Western medication protocols.
Exclusion criteria
Exclusion criteria: 1)Pregnant or lactating women. 2)Patients diagnosed with: Mild or severe generalized anxiety disorder (GAD-7 3×ULN eGFR <30 mL/min) Malignancies Hematologic disorders Cardiovascular/cerebrovascular diseases (e.g. NYHA Class III/IV heart failure recent stroke). 5)Hypersensitivity or intolerance to: Escitalopram oxalate (or its excipients) Sertraline (or its excipients) Acupuncture therapy. 6)Recent interventions (within 30 days prior to enrollment): Acupuncture treatment Psychotropic medications (e.g. antidepressants anxiolytics) Or failure to complete the 30-day washout period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Rating Scale;The Pittsburgh Sleep Quality Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Insomnia Severity Index;The Asberg Side Effect Rating Scale;The Generalized Anxiety Disorder Scale;The 36-Item Short Form Health Survey; | — |
Countries
China
Contacts
Public ContactLiu Jianhua
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed