Type 2 diabetic foot ulcer
Conditions
Interventions
Experimental group:Routine debridement and dressing change+MEBO
Control group:Routine debridement and dressing change
Sponsors
Yantai Yuhuangding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with type 2 diabetes mellitus with foot ulcers. 2. Age =18 years old. 3.Wagner is rated 2-4. 4. There is no obvious necrotic tissue on the wound or the necrotic tissue has been removed by debridement. 5. The infection has been controlled and the wound is in a stable stage. 6. The skin around the wound had no obvious signs of acute infection such as redness swelling and heat pain. 7. No obvious skin diseases such as eczema and dermatitis. 8. Good skin integrity no extensive damage or ulcers. 9. Informed consent for this study can support treatment and follow-up.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women. 2. Smoking years =20 years. 3. Drink more than 3 standard drinks per day or more frequently than 5 times per week. 4. It has developed gangrene and requires amputation. 5. Complicated with major organ dysfunction. 6. Impaired nutritional intake. 7. Other serious complications. 8. Ankle-brachial index < 0.7. 9. Allergic reaction to the ingredients used in this study. 10. Have recently (within 1 month) used other local therapeutic drugs (such as antibiotic ointment growth factor etc.) or received other wound treatment. 11. Inability to cooperate with treatment or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound healing rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wound healing time;Evaluation of disease treatment efficacy;Macrophage mannose receptor(CD206);T lymphocyte activation antigen(CD86);Wound closure index;Local symptom score;Arginase 1(Arg-1);a-smooth muscle actin(a-SMA);Wound infection rate;Pain Visual Analogue Scale;inducible nitric-oxide synthse(iNOS);Platelet endothelial cell adhesion molecule(CD31); | — |
Countries
China
Contacts
Public ContactXiaorui Jiang
Yuhuangding Hospital Yantai City Shandong Province
Outcome results
None listed