1.Hypertension in pregnancy 2.pre-eclampsia
Conditions
Interventions
healthy women of childbearing age group:No intervention measures are involved
preeclampsia group:No intervention measures are involved
women at high risk of preeclampsia during pregnancy group:No intervention measures are involved
gestational hypertension group:No intervention measures are involved
women at low risk of preeclampsia during pregnancy group:No intervention measures are involved
Sponsors
China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: criteria for women at low risk of preeclampsia during pregnancy: Inclusion criteria: Aged 20–40 years old. Confirmed by ultrasound to have a single live intrauterine fetus. Willing and able to participate in all stages of the study. Capable of understanding and signing the informed consent form. high risk of preeclampsia through risk prediction. Refusal to accept follow-up. criteria for healthy women: Inclusion criteria: Non-pregnant. Aged 20–40 years old. No history of major diseases; normal results in laboratory tests (blood lipid blood glucose urinalysis liver function renal function electrocardiogram) and physical examinations (height weight waist circumference hip circumference blood pressure); no organic lesions. Willing and able to participate in all stages of the study. Capable of understanding and signing the informed consent form. criteria for women at high risk of preeclampsia: Inclusion criteria: Identified as high-riskpopulation through preeclampsia risk screening. Aged 20–40 years old. Confirmed by ultrasound to have a single live intrauterine fetus. Willing and able to participate in all stages of the study. Capable of understanding and signing the informed consent form. criteria for gestational hypertension/preeclampsia: Inclusion criteria: Diagnosed with preeclampsia or hypertension (refer to relevant standards). Aged 20–40 years old. Confirmed by ultrasound to have a single live intrauterine fetus. Willing and able to participate in all stages of the study. Capable of understanding and signing the informed consent form.
Exclusion criteria
Exclusion criteria: criteria for women at low risk of preeclampsia during pregnancy: Exclusion criteria: Age below the legal marriageable age. Multiple pregnancies (including twin pregnancies). History of major diseases (regardless of severity) including poorly controlled diabetes previous chronic hypertension untreated or active cancer (excluding any cancer in remission or non-melanoma skin cancer) rheumatoid arthritis severe cardiovascular hepatic or renal diseases pulmonary diseases other than mild asthma neurological diseases requiring medication uncontrolled hypothyroidism uncontrolled epilepsy etc. Unwilling to sign the informed consent. Use of alcohol or other central nervous system depressants (e.g. diazepam phenobarbital etc.). Women assessed as having a high risk of preeclampsia through risk prediction. Refusal to accept follow-up. criteria for healthy women: Exclusion criteria: Same as those for pregnant women except for pregnancy itself. criteria for women at high risk of preeclampsia: Exclusion criteria: Already diagnosed with preeclampsia or hypertension. Presence of any contraindications (e.g. aspirin allergy). Severe medical conditions (e.g. heart disease liver disease kidney disease etc.) that may affect pregnancy progression. Known hereditary diseases or chromosomal abnormalities. Pre-existing hypertension before pregnancy. Unwilling or unable to attend regular prenatal check-ups and follow-ups. Use of medications that may affect preeclampsia risk assessment. Multiple pregnancies (including twin pregnancies). criteria for gestational hypertension/preeclampsia: Exclusion criteria: Severe medical conditions assessed to potentially affect pregnancy progression or pulse pattern analysis. Known hereditary diseases or chromosomal abnormalities. Unwilling or unable to attend regular prenatal check-ups and follow-ups. Pre-existing hypertension before pregnancy. Multiple pregnancies (including twin pregnancies).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pulse wave parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy outcome;Abnormal physical and chemical examination results related to pregnancy outcome;Changes in Quality of Life;Perinatal complications;serum small-molecule metabolites;serum proteins;Ongoing pregnancy rate;Maternal complications;Abortion rate;Overall health assessment; | — |
Countries
China
Contacts
Public ContactZhao Yu-ping
China Academy of Chinese Medical Sciences
Outcome results
None listed