premature ventricular contraction
Conditions
Interventions
control subjects:Cephalosporin Combination Analog + Metoprolol Tartrate Tablets
intervention group:Quintessence of Spleen Combination + Metoprolol Tartrate Tablets
Sponsors
Guang'anmen Hospital China
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age =18 years =75 years and gender; (2) Meet the diagnostic criteria of functional premature ventricular beats in Western medicine and have =720 premature ventricular beats/24 hours on 24-hour ambulatory electrocardiogram; (3) Meet the Chinese medicine diagnostic criteria of heart-spleen deficiency; (4) Compliance with Class II = Lown Class = Class IVa; (5) Symptoms of premature ventricular contractions lasted for more than 1 week; (6) Informed consent and signing the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with comorbid hypertensive disease whose blood pressure control is still unstable after standardized antihypertensive treatment i.e. systolic blood pressure =160 mmHg and/or diastolic blood pressure =100 mmHg; (2) Combined with various structural heart diseases such as coronary heart disease heart failure cardiomyopathy valvular heart disease mitral valve prolapse pacemaker placement etc.; combined with malignant ventricular arrhythmias (e.g. short-paroxysmal ventricular tachycardia tip-twisting ventricular tachycardia ventricular fibrillation etc.) the development of long QT interval syndrome (QT interval =50ms) or severe conduction block (e.g. II III degree) or other supraventricular Arrhythmia; Combined with malignant tumor serious cerebrovascular disease hepatic or renal insufficiency infectious disease hematological or other systemic diseases mental illness; (3) People with premature ventricular contractions caused by drugs electrolyte disorders (hypokalemia hypomagnesemia) anemia hyperthyroidism and other systemic diseases and unknown causes; (4) Those who are allergic to known components of the test drug; (5) Blood creatinine exceeds the upper limit of normal value or either ALT AST exceeds the upper limit of normal value two times; (6) Women who are pregnant or preparing for pregnancy within six months and women who are breastfeeding; (7) Those who are suspected or confirmed to have a history of alcohol addiction or drug abuse; (8) Those who are unable to discontinue antiarrhythmic drugs other than metoprolol tartrate tablets during the participation phase of this clinical trial; (9) Subjects with surgical indications and the subject's desire to undergo surgical treatment; (10) Those who have participated in other clinical trials within 30 days prior to screening; (11) Those who in the opinion of the investigator are not suitable for participation in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of the number of episodes of premature ventricular contractions before and after 24-hour ambulatory electrocardiography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life (SF-36) scores;Chinese medicine evidence assessment;Pittsburgh Sleep Quality Index (PSQI) Scores;Changes from baseline in electrocardiogram indicators; | — |
Countries
China
Contacts
Public ContactJun Li
Guang'anmen Hospital China Academy of Traditional Chinese Medicine
Outcome results
None listed