Severe pneumonia
Conditions
Interventions
Small Airway Function Normal Group:No
Small Airway Dysfunction Group:No
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1)Patients aged 6 to 18 years regardless of gender. (2)Children who meet the diagnostic criteria for pediatric severe pneumonia. (3)Children who meet the traditional Chinese medicine diagnostic criteria for stasis-heat syndrome. (4)Voluntary participation with informed consent obtained from the child and their legal guardian and a signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of other diseases that cause wheezing such as primary ciliary dyskinesia congenital bronchopulmonary dysplasia foreign body aspiration pulmonary tuberculosis cystic fibrosis and children who have undergone umbilical cord blood stem cell transplantation. 2. Presence of severe primary diseases in other systems such as cardiovascular liver kidney and hematopoietic systems or severe malnutrition gastroesophageal reflux primary immunodeficiency psychiatric disorders and other serious diseases that affect their quality of life. 3. Children with potential bleeding risks identified through pre-bronchoalveolar lavage tests of coagulation function and platelet count. 4. Inability to attend regular follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary Function Test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Efferocytosis index;Analyze the correlation between small airway dysfunction and the efferocytosis function of alveolar macrophages;Gene expression levels of the MerTK/Dnase2a/Myc pathway in the AMf efferocytosis process; | — |
Countries
China
Contacts
Public ContactGuojianning
China-Japan Friendship Hospital
Outcome results
None listed