Mild Cognitive Impairment
Conditions
Interventions
Gold Standard: Diagnostic Criteria for Mild Cognitive Impairment (MCI):
Based on the revised 2003 International Working Group diagnostic criteria for Mild Cognitive Impairment (MCI) and the *2018 Ch
(2) Objective evidence of impairment in one or more cognitive domains (from cognitive tests)
(3) Minor impairment in complex instrumental daily activities may be present but independent daily living abilities are preserved
(4) The diagnostic criteria for dementia are not met.
Specific criteria are as follows:
(1) Self-reported or family-reported significant memory impairment
(2) Based on the patients education level:
- Montreal Cognitive Assessment (MoCA) score =13 for illiterate individuals
- MoCA score =19 for those with primary school education
- MoCA score =24 for those with junior high school education or higher
(3) Based on the patients education level:
- Mini-Mental State Examination (MMSE) score >17 for illiterate individuals
- MMSE score >20 for those with primary school education
- MMSE score >24 for those with junior high school education or higher
(4) Activities of Daily Living (ADL) score <22 with no more than one item scoring =3
(5) Clinical Dementia Rating (CDR) score of 0 or 0.5.
Index test:The score of the Chinese Smell Identification Test(CSIT)
Sponsors
General Hospital of the Western Theater Command of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Participants must meet all of the following four criteria to be included in this study: (1) Age 50–85 years; (2) No significant speech vision or hearing impairments and capable of completing neuropsychological assessments and related evaluations; (3) Sufficient comprehension ability to make independent judgments and fully understand the purpose content and procedures of the study; (4) Voluntary participation in the study willingness to cooperate in completing olfactory identification tests and cognitive function assessments and signing of an informed consent form.
Exclusion criteria
Exclusion criteria: Participants meeting any of the following criteria will be excluded: (1) Diagnosed with dementia or currently taking cognitive-enhancing medications; (2) Cognitive impairment caused by other conditions such as acute cerebrovascular disease central nervous system infections intracranial space-occupying lesions Parkinsons disease traumatic brain injury thyroid and parathyroid disorders diabetes poisoning epilepsy syphilis psychiatric disorders or severe vitamin deficiencies; (3) History of nasal fractures or nasal surgery or presence of olfactory dysfunction-related conditions (e.g. chronic rhinitis allergic rhinitis nasal polyps) or upper respiratory tract infection within the past two weeks; (4) Long-term or heavy exposure to volatile substances such as pesticides herbicides metal dust acid fumes industrial solvents cleaning products or sawdust; (5) History of drug abuse or heavy alcoholism within the past two years or long-term use of medications that affect cognitive function (e.g. corticosteroids antipsychotics sedative-hypnotics); (6) Pseudo-cognitive impairment due to mood disorders (e.g. moderate to severe depression) with a Hamilton Depression Scale (HAMD) score =18; (7) Intellectual disability or neurodevelopmental delay; (8) Current participation in other clinical trials involving cognitive interventions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment(MoCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Dementia Rating(CDR);Activities of Daily Living(ADL;Mini-Mental State Examination(MMSE);Hamilton Depression Scale(HAMD);the Chinese Smell Identification Test(CSIT); | — |
Countries
China
Contacts
Public ContactPang Rizhao
General Hospital of the Western Theater Command of the Chinese People's Liberation Army
Outcome results
None listed