hepatocellular carcinoma
Conditions
Interventions
Chinese herbal group:Basic treatment+HIFU+Chinese herbal granules
Control group:Basic treatment+HIFU
Sponsors
Shanghai Municipal Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Meet the clinical or/or pathological diagnostic criteria for primary hepatocellular carcinoma; (2) CNLC stage IIB-IIIB advanced liver cancer; (3) Those who are unable to tolerate invasive local treatments such as TACE or who are resistant to TACE treatment or ineffective treatment; (4) Measurable primary lesions confirmed by CT or MRI imaging examination; (5) The patient's physical condition is still good and the physical condition score (Karnofsky) = more than 60 points; (6) The function of all important organs is basically normal and the expected survival time is more than 3 months; (7) All those who have completed surgery radiotherapy TACE and other treatments for more than 3 months and the adverse reactions have recovered after treatment; (8) If it is combined with obstructive jaundice it must be treated with ERCP biliary stent drainage; (9) Voluntarily accept HIFU treatment and sign the informed consent form with good compliance.
Exclusion criteria
Exclusion criteria: (1) Skin ulceration or infection at the ultrasound treatment channel; (2) Combined with other serious underlying diseases such as heart lung and renal failure; (3) Severe coagulation dysfunction or clear bleeding tendency; (4) Patients with moderate or above ascites; (5) There were obvious calcified plaques in the arterial wall of the ultrasound treatment channel; (6) Child-Pugh grade C of liver function; (7) Have severe psychological or psychiatric abnormalities in the past and the compliance with the estimated participation in this study is insufficient.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression free survival;Dynamic contrast enhanced magnetic resonance imaging parameter;Tumor markers;Karnofsky score; | — |
Countries
CHina
Contacts
Public ContactYuli Wang
Shanghai Municipal Hospital of Traditional Chinese Medicine
Outcome results
None listed