Vascular Dementia
Conditions
Interventions
Normal control group:Without any intervention
Sponsors
The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Research object selection: Thirty normal elderly patients aged 50-85 years and 80 patients with VD were selected. The purpose of setting up the normal control group is to take its data as the baseline to understand the characteristics of immunoinflammatory injury in patients with VD and the regulation effect of acupuncture. A. Inclusion criteria for normal elderly Age 50-85 years old male or female with a junior high school education or above; There may be a history of hypertension coronary heart disease diabetes and other past medical history but must be stable control. B. Diagnostic criteria for VD patients Diagnostic criteria of western medicine According to the 2019 Chinese Guidelines for the Diagnosis and Treatment of Vascular Cognitive Disorders issued by the Cognitive Disorders Professional Committee of the Neurology Branch of the Chinese Medical Doctor Association and the 2014 VASCOG Consensus issued by the International Society for Vascular Behavior and Cognitive Disorders: Diagnostic criteria for Vascular Cognitive Impairment and mild to moderate dementia was determined according to Clinical Dementia Scale (CDR) criteria. TCM diagnostic criteria There is no name of VD disease in Chinese medicine literature but according to its pathogenesis and clinical manifestations it belongs to the categories of "forgetfulness" "stupidness" and "dementia" in Chinese medicine. This study referred to the "Clinical Guiding Principles for the Treatment of senile Dementia with New Chinese Medicines" in the "Guiding Principles for Clinical Research of New Chinese Medicines" issued by the Ministry of Health in 2002 the "Criteria for Diagnosis differentiation and efficacy Evaluation of vascular Dementia" compiled by Tian Jinzhou and the "Planning textbooks for National Colleges of Traditional Chinese Medicine · Internal Medicine of Chinese Medicine in the New Century (second edition)" The scale for the differentiation of syndromes of vascular dementia (SDSVD) was used for TCM differentiation of vascular dementia. They are kidney essence deficiency syndrome phlegm turbidness blocking the body syndrome blood stasis blocking collaterals syndrome liver-yang hyperactivity syndrome fiery internal excessive syndrome fu-organ stagnation syndrome Qi and blood deficiency syndrome. The full score of each syndrome is 30 points =7 points is the diagnosis of the syndrome is established; =7 to 14 is classified as mild =15 to 22 as moderate =23 to 30 as severe. C. VD patient inclusion criteria (1) Meet the above diagnostic criteria for vascular dementia; (2) meet the diagnostic criteria for multiple infarct dementia or subcortical arteriosclerotic encephalopathy; (3) Meet the moderate mild and moderate criteria of the Clinical Dementia Rating Scale (CDR); (4) Summary Mental Status Examination (MMSE) score ?24 points (secondary school or above); ?20 marks (primary level) ?17 marks (illiterate); (5) Hachinski Ischemia Scale (HIS) score ?7 points; (6) Hamilton Depression Scale = 17 points; (7) Age 50-85 years old male or female female should be sterile postmenopausal women (at least 1 year menopause); (8) Subjects voluntarily participate in clinical trials and sign informed consent; (9) Have a correct understanding of the significance of this study and have good compliance; (10) Have a certain degree of education can read simple newspaper articles in the past conscious no language barriers can cooperate with the completion of relevant scales.
Exclusion criteria
Exclusion criteria: Exclusion criteria for VD patients (1) Alzheimer's disease or other causes of dementia does not meet the diagnostic criteria for vascular dementia; (2) Depression or other mental disorders; (3) Cognitive impairment due to head injury; (4) Have a history of epilepsy encephalitis or other diseases that can cause dementia such as Parkinson's disease Huntington's disease Pick's disease etc.; (5) have certain disorders that can interfere with the assessment of cognitive function including alcohol use or have been diagnosed as a drug or other psychoactive substance abuser by the DSM-IV criteria within the past 5 years; (6) Patients with severe neurological impairment such as convenient hand hemiplegia various aphasia audio-visual impairment etc.; (7) Patients with serious heart lung liver kidney hematopoietic system endocrine system diseases; (8) Patients who have received similar treatment in the past 30 days. Exclusion criteria for normal elderly people There is a history of cerebrovascular disease and cognitive impairment; there are other neurological disorders; there are severe systemic diseases such as severe infection immune system diseases malignant tumors severe liver and kidney dysfunction blood diseases etc. or there is a history of internal diseases such as hypertension diabetes coronary heart disease etc. and they have not been stably controlled; there are mental disorders such as anxiety and depression; recent viral and bacterial infections; history of exposure to chemical toxins; recent use of drugs that affect the immune system.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral Treg homeostasis and function;cognitive ability;Peripheral cytokine levels; | — |
Countries
China
Contacts
Public ContactZhangXuezhu
The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed