Type 2 diabetes
Conditions
Interventions
Control group:Non-vagus nerve stimulation of the external ear
Sponsors
China Academy of Chinese Medical Sciences Wangjing hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1)Meets the diagnostic criteria for type 2 diabetes (T2D); (2)Aged between 18 and 70 years regardless of sex; (3)Experiences nausea and vomiting after semaglutide injection with a Rhodes Index of Nausea Vomiting and Retching (RINVR) score of =20 and =32; (4)After consuming a test meal (egg sandwich + 200 ml water) presents with an electrogastrogram (EGG) showing a dominant frequency lower than 2.4 cycles per minute (cpm) no significant increase in power spectral density and reduced frequency and amplitude of tachygastria; (5)Provides a signed informed consent form.
Exclusion criteria
Exclusion criteria: (1)Patients with severe diseases of the heart brain liver hematopoietic system or other serious illnesses that affect survival; (2)Patients with hepatic or renal insufficiency or liver cirrhosis; (3)Patients with high fever or infectious diseases; (4)Pregnant or lactating women; (5)Patients with psychiatric disorders or those unable to cooperate with treatment; (6)Patients with a known or suspected allergy to the treatment used in this study; (7)Patients with acute pancreatitis diabetic retinopathy or thyroid diseases; (8)Patients currently taking prokinetic drugs or other medications that may alleviate nausea and vomiting (e.g. ondansetron metoclopramide dexamethasone); (9)Patients with other gastrointestinal disorders associated with nausea and vomiting (e.g. diabetic gastroparesis functional dyspepsia); (10)Patients who have participated in other clinical trials within the past 3 months and are at potential risk of interfering with this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rhodes index of nausea vomiting and retching; | — |
Secondary
| Measure | Time frame |
|---|---|
| Electrogastrogram;Simplified Nutritional Appetite Questionnaire;serological marker;Visual Analogue Scale; | — |
Countries
China
Contacts
Public ContactXu Zhai and Xinyi Tian
China Academy of Chinese Medical Sciences
Outcome results
None listed