Postoperative delirium
Conditions
Interventions
taVNS group:The patients tragus was stimulated using transcutaneous auricular vagus nerve
sham stimulation group:The patients earlobe was stimulated using transcutaneous auricular vagus nerve
Sponsors
People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 65-80 years 2. American Society of Anesthesiologists (ASA) physical status II–III 3. Scheduled for elective unilateral total knee arthroplasty under general anesthesia 4. Able to provide written informed consent 5. Sufficient comprehension of Mandarin Chinese to follow study instructions
Exclusion criteria
Exclusion criteria: 1. Baseline dementia diagnosed using DSM-5 criteria 2. Montreal Cognitive Assessment score <19 3. Implanted electrical devices (e.g. pacemakers deep brain stimulators) 4. Active infection at the auricular acupuncture sites 5. Severe hematological or hemorrhagic disease 6. Severe sensory impairments preventing reliable cognitive assessment 7. Current alcohol or illicit drug use disorder 8. Current use of sedatives antidepressants or glucocorticoids 9. Receipt of acupuncture or electroacupuncture within one month before surgery 10. Any condition deemed unsafe for trial participation by the research team
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium within 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain score;Cognitive function;Sleep quality;Recovery quality;Cerebral perfusion;Hospital length of stay;Delirium subtype;Inflammatory markers;Autonomic function;Psychological status;The incidence of major postoperative complications;Delirium severity;30-day readmission rates; | — |
Countries
China
Contacts
Public ContactLei Chen
People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine
Outcome results
None listed