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Intervention Effects and Biomarker Exploration of Traditional Chinese Herbal Medicine Polyp Prevention Formula on Colorectal Polyp Recurrence: A Study Integrating Network Pharmacology and Mendelian Randomization

Study on the intervention effect of polyp prevention formula on postoperative recurrence of colorectal polyps

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001131
Enrollment
Unknown
Registered
2025-06-06
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal polyp

Interventions

Control Group:Oral Chinese medicine granules placebo for 2 months.
Observation Group:patients received the Polyp Prevention Formula (granules containing Atractylodes macrocephala 6g Cyperus rotundus (vinegar-processed) 6g Angelica sinensis 6g Codonopsis pilosula 6g P

Sponsors

Beijing Rectum Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients meeting endoscopic and pathological diagnostic criteria for colorectal polyps. Age 18–80 years male or female. Traditional Chinese Medicine (TCM) syndrome differentiation: intestinal dampness-heat syndrome or spleen deficiency with dampness retention syndrome. Adequate bowel preparation (Boston Bowel Preparation Scale score of 2–3 across all colon segments). Willingness to sign informed consent and complete questionnaires.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: Severe cardiovascular cerebrovascular pulmonary hepatic or renal comorbidities. Colorectal malignancy (including early-stage cancer). Pregnancy. Psychiatric disorders affecting compliance. Active inflammatory bowel disease. Uncontrolled systemic malignancies.

Design outcomes

Primary

MeasureTime frame
Polyp recurrence rate at Year 2;

Secondary

MeasureTime frame
mRNA expression changes of core targets.;Protein expression changes of core targets.;

Countries

China

Contacts

Public ContactGao Xudong

Beijing Rectum Hospital

woyunjushi@163.com13810988684

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026