Acute ischemic stroke
Conditions
Interventions
control group:conventional therapy
Treatment group:Three points bleeding therapy combined with conventional therapy
Sponsors
Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The affiliated hospital of Hunan Academy of Traditional Chinese Medicine)
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnosis of AIS(refer to the diagnostic criteria for AIS formulated in the "Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2023": a. Acute onset b. Defects in the local kitchen nerve function with a few cases being generalized neurological deficits; c. The imaging shows the responsible lesion or symptoms/signs for more than 24 hours; d. Rule out non-vascular causes; e. Brain CT/MRI to rule out cerebral hemorrhage; 2. Within 7 days of acute onset; 3.18 years old or younger gender not limited; 4.NIHSS=4 points; 5. Voluntary participation: The patient or their immediate family members can and are willing to sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Transient ischemic attack or cerebral embolism caused by brain tumor brain trauma cardiogenic embolism etc.; 2. Patients who had received other vascular opening treatments before enrollment such as intra-arterial thrombolysis endovascular thrombectomy angioplasty and stenting etc. 3. Patients who received thrombolytic therapy before enrollment including recombinant tissue plasminogen activator urokinase tenecteplase etc. or intravenous antiplatelet drugs such as tirofiban; (4) a history of severe coagulopathy systemic bleeding (including platelet count 1.7 or PT>15s); 5. Patients with serious primary diseases of cardiovascular hepatic renal and hematopoietic systems and psychiatric disorders (including addiction and drug use disorders dissociative disorders and schizophrenia); 6. Patients who are pregnant lactating or have recent plans to have children.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of patients with good outcomes;Glasgow Coma Scale;National Institutes of Health Stroke Scale score;Modified Barthel Index;All-cause mortality rate;Stroke recurrence rate; | — |
Countries
China
Contacts
Public ContactWu Dahua
Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine (The affiliated hospital of Hunan Academy of Traditional Chinese Medicine)
Outcome results
None listed