Post-stroke cognitive impairment
Conditions
Interventions
Moxibustion group:Acupuncture at RN8 + conventional internal medicine basic treatment and rehabilitation therapy
Moxibustion control group:Place the intelligent electronic moxibustion device at Shenshu point for heating+conventional internal medicine basic treatment and rehabilitation therapy
Sponsors
Dongfang Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for PSCI patients: (1) Conform to the above-mentioned PSCI diagnostic criteria; (2) 10 = MoCA score of Montreal Cognitive Assessment Scale < 26; (3) Age range of 30 to 75 years old no gender requirement; (4) Duration of disease ranging from 1 month to 1 year; (5) No use of drugs for improving cognitive function before enrollment; (6) Consciousness clear stable vital signs; (7) Voluntary participation in this study and signing the informed consent form. Inclusion criteria for healthy subjects: (1) Age between 18 and 65 years old with no gender restrictions.(2) Confirmed to have no significant diseases through a systematic health examination in good physical condition and without a history of major diseases (such as cardiovascular and cerebrovascular diseases neurological disorders immune system disorders digestive system diseases etc.).(3) Confirmed to have normal cognitive function through cognitive function assessment with no cognitive impairment or mental disorders.(4) Able to understand the research content and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria for PSCI patients: (1) There are other diseases that can lead to cognitive impairment such as intracranial space-occupying lesions brain trauma and arteriovenous malformations etc.(2) There are diseases that seriously affect cognitive function tests such as abnormal auditory and visual functions mental disorders and inability to cooperate with diagnosis and treatment.(3) There was obvious cognitive decline or dementia history before this onset.(4) There are other serious diseases such as immune diseases endocrine diseases abnormal liver and kidney functions or severe bleeding tendencies.(5) Pregnant or lactating women.(6) Those who are allergic or intolerant to moxibustion.(7) Those who are participating in other clinical trials. Exclusion criteria for healthy subjects: (1) Have used antibiotics probiotics immunomodulators or other drugs or health supplements that may affect the composition of the intestinal flora within the last three months.(2) Have a history of gastrointestinal surgery or chronic gastrointestinal diseases (such as inflammatory bowel disease irritable bowel syndrome etc.).(3) Have acute or chronic inflammatory diseases infectious diseases or other conditions that may interfere with the stability of the intestinal flora.(4) Pregnant women lactating women and other special groups whose physiological conditions may affect the flora data.(5) Have a long-term habit of heavy drinking smoking or other lifestyle issues that may significantly affect the composition of the intestinal flora.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment,MoCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Determination of Short-Chain Fatty Acids in Feces by Gas Chromatography – Mass Spectrometry (GC-MS);Blood index testing;Hamilton Anxiety Scale,HAMA;Mini-mental State Examination,MMSE;Microbial Population Analysis Based on 16S rRNA Detection;Modified Barthel Index,MBI;Pittsburgh Sleep Quality Index,PSQI;Hamilton Depression Scale,HAMD; | — |
Countries
China
Contacts
Public ContactYU Mengyun
Dongfang Hospital Beijing University of Chinese Medicine
Outcome results
None listed