Cognitive impairment after stroke
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. The subject meets the diagnostic criteria for ischemic or hemorrhagic stroke and at the same time is diagnosed with post-stroke cognitive impairment (Expert Consensus on the Management of Post-stroke Cognitive Impairment (2021)) 2.Patients with neuroimaging-confirmed stroke; 3.According to the Expert Consensus on the Management of Cognitive Impairment after Stroke (2021) the Montreal Cognitive Assessment Scale (MoCA) <26;State Test (MMSE): MMSE score < 17 (illiterate) or MMSE score < 20 (primary school literacy) or MMSE score < 24 (secondary school and above); 4.Men and women between the ages of 30 and 70 years; 5.The patient signed the informed consent form to cooperate with the treatment;
Exclusion criteria
Exclusion criteria: 1.Have Alzheimer's disease Parkinson's disease frontotemporal dementia Huntington's disease demyelinating disease post-traumatic cognitive impairment or diseases such as central nervous system infections; 2.Previous medical conditions such as epilepsy psychosis or brain tumors; 3.Alanine aminotransferase or aspartate aminotransferase >2 times the upper limit of normal or severe liver disease; 4.Glomerular filtration rate <30mL/min/1.72m2 or severe renal disease; 5.Severe visual or hearing impairment severe aphasia that may affect the assessment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MOCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination (MMSE);Lovington Homework Therapy Cognitive Assessment Kit (LOTCA);Activities of Daily Living Scale (ADL);fNIRS brain function measurement; | — |
Countries
china
Contacts
Rongjun Hospital of Hubei Provincial