Insomnia and depression
Conditions
Interventions
mild to moderate depression patients (MDD group):acupuncture at HT7
Healthy Control (HC group):acupuncture at HT7
Chronic insomnia patients(CI group):acupuncture at HT7
Healthy Control (HC group):sham acupuncture at HT7
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for healthy subjects 1) Denial of neurological or psychiatric disease history and family history 2) No experience of acupuncture and similar therapies 3) Education degree above high school 4) Right-handed 5) No history of acupuncture dizziness no serious liver kidney digestive hematopoietic diseases and other contraindications 6) Age 18-35 years old 7) Sign informed consent 2. Patients with insomnia were included in the criteria 1) Meet the diagnostic criteria for insomnia; Denial of any history of other neurological or psychiatric disorders or family history; (3) Pittsburg sleep scale score > 16; 4) Age 18-65 years old; 5) The others were the same as the healthy subjects. 3 Mild and moderate depression patients 1) Meet the DSM-V diagnostic criteria for depression with mild or moderate attacks; Denial of other neurological or psychiatric disease history and family history; (3) 24 items of Hamilton Depression Scale: 9 < total score < 27 and all answers to suicide severity rating scale were "no" or s
Exclusion criteria
Exclusion criteria: 1) Healthy subjects 1) Insomnia depression anxiety and other mental diseases; History of use of psychotropic drugs in the last 3 months including but not limited to antidepressants sleeping pills etc.; (3) A blood related relative within three generations has a history of mental illness; 4) Claustrophobia; (5) Infection allergy and trauma of acupuncture site. 2) Chronic insomnia patients and mild to moderate depression patients 1) combined with other neurological and psychiatric diseases; In the last 3 months there has been a change in the use of psychotropic or potentially affecting brain functional activities of drugs (including but not limited to antidepressants sleeping pills); 3)The others were the same as the healthy subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fMRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton's Depression Scale (MDD and CI group);Pittsburgh Sleep Quality Index;Hamilton anxiety scale;Massachusetts Hospital Acupuncture Sensation Scale; | — |
Countries
China
Contacts
Public ContactHe Jiakai
Peking University People's Hospital
Outcome results
None listed