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A prospective, multicenter clinical study on the prevention and treatment of hand-foot skin reactions caused by anti-tumor targeted drugs with Tongluo SAN

A prospective multicenter clinical study on the prevention and treatment of hand-foot skin reactions caused by anti-tumor targeted drugs with Tongluo SAN

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2025001019
Enrollment
Unknown
Registered
2025-05-22
Start date
2025-05-30
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hand-foot skin reaction

Interventions

Test Group:Urea ointment and contact particles
Control Group:Urea ointment and placebo particles

Sponsors

China-japan Friendship Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) patients with pathologically confirmed malignancies including liver cancer kidney cancer breast cancer lung cancer etc.; 2) Grade 1 or higher HFSR after receiving polykinase inhibitor targeted drug treatment including sorafinil shunitinib etc.; 3) Age 18 to 80 years; 4) U.S. Eastern Tumor Collaboration Group score (ECOG score): 0 to 2 points; 5) Expected survival = 3 months; 6) No serious organ dysfunction heart liver kidney etc. tests are basically normal; 7) Able to communicate normally and sign informed consent.

Exclusion criteria

Exclusion criteria: 1) the presence of other skin lesions in the hands and feet (such as peripheral neuropathy caused by diabetes or chemotherapy hand and foot syndrome fungal infection of the hands and feet skin trauma inflammation etc.); Use in combination with other drugs that may affect HFSR.

Design outcomes

Primary

MeasureTime frame
Treatment Efficiency;

Secondary

MeasureTime frame
Pain Relief Rate;Targeted treatment completion rate;HF-QOL;

Countries

China

Contacts

Public ContactLiqun-jia

China-japan Friendship Hospital

Liqun-jia@hotmail.com13601231765

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026