NSAA
Conditions
Interventions
Control Group:placebo + western medicine treatment
Test Group:Wenyang Shengxue Tang + western medicine treatment
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Western Medical Diagnostic Criteria (NSAA Compliant) (1) Clinical manifestation: The onset of acute aplastic disorder is slower and anemia infection and bleeding are relatively mild. (2) Blood routine: hemoglobin decrease rate is slower reticular neutrophil and platelet decrease but can not reach the degree of acute restoration. (3) Bone marrow routine: three-line or two-line decrease at least one part of the poor proliferation active proliferation the relative increase of lymphocytes and the obvious decrease of megakaryocyte; Non-hematopoietic cells such as fat cells increase in bone marrow granules. (4) In the course of the disease if the disease worsens and the clinical blood and bone marrow images are the same as those of severe aplastic disorder type ? of severe aplastic disorder will be weighed. A Those who meet the above diagnostic criteria for western medicine are older than 18 years old and meet the diagnosis of "kidney yang deficiency" syndrome in traditional Chinese medicine. They can be included in clinical treatment research when the following points are met: B can exclude other diseases that cause reduction of whole blood cells such as myelodysplastic syndrome myelofiberization acute hematopoietic arrest idiopathic sleep hemoglobin urine acute leukemia malignant histiocytosis etc .; C the treatment of general anti-anemia drugs is ineffective; D Voluntary treatment with traditional Chinese medicine an informed consent form should be signed before inclusion; E can follow up good compliance can be included in the project.
Exclusion criteria
Exclusion criteria: Severe primary diseases such as heart liver kidney and lung as well as psychiatric patients; Patients who received ATG/ALG treatment within the first 3 months of enrollment in group B; Pregnant or lactating women; D has other malignant diseases or a second blood disease that have not yet recovered combined with uncontrollable severe infections; Simultaneously participating in other studies or deemed unsuitable for inclusion by the researcher; Traditional Chinese Medicine (TCM) syndrome types are relatively complex with multiple mixed types.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficiency of Traditional Chinese and Western Medicine;Efficiency of Traditional Chinese Medicine; | — |
Secondary
| Measure | Time frame |
|---|---|
| AR;cytokines;blood routine examination;Sex hormone expression levels;Blood transfusion frequency;Thyroid function tests ;Blood transfusion frequency;bone marrow;T cell subset;GR;Bone marrow microvasculature; | — |
Countries
China
Contacts
Public ContactDeng Shu
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)
Outcome results
None listed