Gastrointestinal Dysfunction Associated with Sepsis
Conditions
Interventions
Observation group:Basic treatment + Fuzheng Tongfu Jiedu prescription
Control group:Basic treatment + Fuzheng Tongfu Jiedu prescription placebo
Sponsors
Dongzhimen Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) The diagnosis was consistent with sepsis-induced gastrointestinal dysfunction characterized by the TCM syndrome of deficiency in fu-organs with concurrent stasis of solid toxins. AGI grading was classified as Grade I-III; (2) Patients aged between 50 and 90 years inclusive of any gender; (3) SOFA score: =2 points; (4) Diagnosis of sepsis-induced gastrointestinal dysfunction within 24 hours; (5) Voluntary participation in this study with signed informed consent.
Exclusion criteria
Exclusion criteria: (1) The frequency of watery stool and diarrhea exceeds three times daily with a total volume greater than 1500 mL. (2) Changes in gastrointestinal function could not be evaluated due to ICU stays shorter than seven days (e.g. death discharge transfer out of ICU). (3) Abdominal pressure and circumference could not be measured in patients with excessive weight (weight > 150 kg) or those who have undergone trauma or surgery. (4) Patients with severe organic diseases including end-stage hematologic malignancies decompensated liver cirrhosis HIV and other serious underlying conditions that pose an imminent risk to life. (5) Patients who have undergone gastrointestinal surgery. (6) Patients on long-term use of hormones immunosuppressants or other medications. (7) Patients with severe psychiatric disorders or unable to participate in the study. (8) Participants who have enrolled in other clinical trials within the past 30 days. (9) Pregnant or lactating women. (10) Patients with allergies to traditional Ch
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AGI classification; | — |
Secondary
| Measure | Time frame |
|---|---|
| FABP;T cell functional subsets detection;Lymphocyte subsets;PCT;CIT;TCM syndrome score;DAO;Gastrointestinal symptom score;abdomen circumference;Blood routine +CRP;Cytokine;SOFA score;Immune factor;Abdominal pressure;28-day mortality rate;D-lactic acid;APACHE ? score;ICU stay; | — |
Countries
China
Contacts
Public ContactLIU Jin
Dongzhimen Hospital Beijing University of Chinese Medicine
Outcome results
None listed